Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever. 9049422 1997
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE Tumor Necrosis Factor Receptor-Associated Factor 5 Interacts with the NS3 Protein and Promotes Classical Swine Fever Virus Replication. 29874812 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE TNF-receptor-associated periodic syndrome (TRAPS) is a hereditary fever syndrome that results from mutations in the TNF-receptor superfamily 1A gene (TNFRSF1A). 16030167 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE The two infants homozygous for the TNF alpha promoter allele 2 had both a much higher incidence of fever, independently of parasitaemia, than the average for the other genotypes. 10223213 1999
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE The most common grade 1-2 adverse events of rmhTNF-α were drug-related fever, allergy, flu-like symptoms, and myalgia. 22085427 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE TNF-308A was the only allele associated with fever, poor performance status, elevated beta2-microglobulin, TNF and its p75 receptor plasma levels. 17311253 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The brains were removed and ipsilateral cortical tissue and hippocampus were dissected and subsequently assayed for interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Hyperthermia occurred during days 1-6 post-CCI in male rats, but only on the day of CCI in female rats, and minocycline prevented its occurrence in both sexes. 29179648 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Mutations in the extracellular domain of the 55-kD tumor-necrosis factor (TNF) receptor (TNFRSF1A), a key regulator of inflammation, define a periodic-fever syndrome, TRAPS (TNF receptor-associated periodic syndrome [MIM 142680]), which is characterized by attacks of fever, sterile peritonitis, arthralgia, myalgia, skin rash, and/or conjunctivitis; some patients also develop systemic amyloidosis. 11443543 2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Tumor necrosis factor shares with IL-1 many of the systemic and local effects of IL-1; these include fever, acute phase protein synthesis and sleep. 3127333 1987
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Isolated, hyperthermic limb perfusion (ILP) with recombinant human tumor necrosis factor alpha and melphalan is a highly effective treatment for advanced soft tissue sarcoma (STS) and locoregional metastatic malignant melanoma. 12149303 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Pro-inflammatory cytokines including TNF, IL-1alpha, IL-1beta and IL-1Ra cause systemic inflammatory reactions and numerous changes including altered cell signaling and migration, changes in cytokine production and fever. 19747989 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Furthermore, leukopenia, lymphocytopenia, differentiation of T-cells, and the secretion of cytokines associated with inflammation or apoptosis such as interferon alpha (IFN-α), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, and IL-10 were induced by the virulent CSFV infection, the differences reflected in onset and extent of the regulation. 29953916 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Complex of TNF-α and Modified Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Suppresses Tumor Growth by Magnetic Induction Hyperthermia. 29265918 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever. 16941196 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE These results suggest that superoxide free radicals or their reaction products are responsible for much of the synergistic cytotoxicity of TNF-alpha and hyperthermia. 9157996 1997
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE These results suggest that the evaluation of TNF/cachectin and LT production in lymphomas may help to elucidate the mechanisms of tumoral fever and cachexia. 2302463 1990
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Under the term "periodic fevers" are gathered some monogenic diseases (familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated syndrome) characterized by periodic or recurrent episodes of systemic inflammation causing fever often associated with rash, serositis (peritonitis, pleuritis), lymphadenopathy, arthritis, and other clinical manifestations. 18368292 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Neither the tumor necrosis factor-α (TNFα) inhibitor etanercept nor the IL-6 receptor antibody tocilizumab abolished the LPS induced fever in IL-1R1 KO mice. 28655587 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype CTD_human Absence of severe systemic toxicity after leakage-controlled isolated limb perfusion with tumor necrosis factor-alpha and melphalan. 10379864 1999
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Lipopolysaccharide-induced fever and TNF-α, interleukin-1β, and interleukin-6 levels were inhibited by MHD. 28332176 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Familial Mediterranean fever (FMF), mevalonate-kinase deficiency (MKD) and tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are the three monogenic disorders subsumed under the term periodic fevers, while a systemic inflammation dominated by a characteristic urticarial rash associated with a number of other clinical manifestations is typical of familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurological cutaneous and articular syndrome (CINCA). 22714396 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Inflammation in various organs is hallmark of tumor necrosis factor-associated periodic syndrome and manifests as spiking fever, abdominal pain, conjunctivitis and polyserositis in adults. 28942479 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Lymphocytes infiltrating damaged tissues might be responsible for the disease through secretion of cytokines, such as tumor necrosis factor (TNF)-alpha, that could cause fever, as well as endothelial tissue damage. 10997339 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (<i>n</i> = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [<i>n</i> = 5], enteroviral meningitis [<i>n</i> = 10], nonspecific viral illness without central nervous system involvement [<i>n</i> = 10]). 29913529 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Transcription of TNF-α<sup>4</sup>; IL-1B,<sup>5</sup> TNFAIP3<sup>6</sup> and IL-8<sup>7</sup> were induced in HaCaT cells subjected to hyperthermia. 29807809 2018