Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. 31549293 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE TonEBP (+/-) mice show reduced sickness responses, which include anorexia and hyperthermia, that are initially induced by tumor necrosis factor (TNF)-α. TonEBP (+/-) mice also show lower levels of TNF-α-induced hypothalamic expression of POMC and pro-inflammatory cytokines. 31281956 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE During mild SI, H<sub>2</sub> reduced plasma surges of proinflammatory cytokines (TNF-α and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever. 30261305 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE In this study, we examined the possible effects of anti-Ly6G-mediated systemic neutrophil depletion and liposome-encapsulated clodronate (LEC)-mediated systemic macrophage depletion on the inflammatory signs (thermal hyperalgesia, mechanical allodynia, oedema and fever) and measured the levels of various inflammation markers (tumour necrosis factor-α (TNF-α), interleukins (IL)-1β, IL-4, IL-10, macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) and myeloperoxidase (MPO) in paw and spinal cord tissues in carrageenan (CG)-induced hindpaw inflammation model in rats. 30680651 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Proinflammatory cytokines, tumor necrosis factor α, interleukin 1 (IL-1), IL-2, interferon γ (IFNγ), and macrophage chemoattractant protein 1 elicit fever, inflammation, multiple organ injury, hypotension, and lethal shock. 30909619 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The CRP, PCT, interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were determined within 6 h of fever onset. 30684912 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The brains were removed and ipsilateral cortical tissue and hippocampus were dissected and subsequently assayed for interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Hyperthermia occurred during days 1-6 post-CCI in male rats, but only on the day of CCI in female rats, and minocycline prevented its occurrence in both sexes. 29179648 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Furthermore, leukopenia, lymphocytopenia, differentiation of T-cells, and the secretion of cytokines associated with inflammation or apoptosis such as interferon alpha (IFN-α), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, and IL-10 were induced by the virulent CSFV infection, the differences reflected in onset and extent of the regulation. 29953916 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation phenotype BEFREE Tumor Necrosis Factor Receptor-Associated Factor 5 Interacts with the NS3 Protein and Promotes Classical Swine Fever Virus Replication. 29874812 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Cellular studies indicated that moderate hyperthermia treatment can increase the mRNA and protein expression of IL-6 and IL-10, while not IL-2, IL-4, IL-8, IL-22, VEGF, TGF-β, or TNF-α, in HCC cells. 29894725 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Inflammation in various organs is hallmark of tumor necrosis factor-associated periodic syndrome and manifests as spiking fever, abdominal pain, conjunctivitis and polyserositis in adults. 28942479 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (<i>n</i> = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [<i>n</i> = 5], enteroviral meningitis [<i>n</i> = 10], nonspecific viral illness without central nervous system involvement [<i>n</i> = 10]). 29913529 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Transcription of TNF-α<sup>4</sup>; IL-1B,<sup>5</sup> TNFAIP3<sup>6</sup> and IL-8<sup>7</sup> were induced in HaCaT cells subjected to hyperthermia. 29807809 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Vehicle-treated rats displayed (i) hyperthermia; (ii) suppressed left ventricular function; (iii) decreased contents of cardiac total antioxiant capacity (e.g., superoxide dismutase, glutathione peroxidase, catalase); (iv) increased contents of cardiac oxidative capacity malondialdehyde and thiobarbituric acid reactive substances; (v) increased cardiac levels of pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6; and (vi) decreased cardiac levels of an anti-inflammatory cytokine interleukin 10. 28104348 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Complex of TNF-α and Modified Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Suppresses Tumor Growth by Magnetic Induction Hyperthermia. 29265918 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Neither the tumor necrosis factor-α (TNFα) inhibitor etanercept nor the IL-6 receptor antibody tocilizumab abolished the LPS induced fever in IL-1R1 KO mice. 28655587 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Lipopolysaccharide-induced fever and TNF-α, interleukin-1β, and interleukin-6 levels were inhibited by MHD. 28332176 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons). 27992852 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Additionally, both NB and SB exhibited remarkable anti-inflammatory effects to reduce the level of inflammatory factors including NO, TNF-α and IL-6 in LPS-induced RAW 264.7 macrophages, and lower the high body temperature in rats with endotoxic fever induced by LPS. 28858264 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1β, IL-6, and TNF-α) release, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) synthesis (both peripherally and hypothalamic)]. 28667503 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE In particular, TNFα is implicated in physiological processes, including fever, energy balance, and autonomic function, known to involve the hypothalamic paraventricular nucleus (PVN). 28385632 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Therefore, TNF inhibitors could shorten the duration of fever in IVIG-resistant KD. 27550227 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE ThermomiRs such as miR-142-5p and miR-143 in turn target endogenous pyrogens including IL-6, IL6ST, TLR2, PGE2 and TNF to complete a negative feedback mechanism, which may be crucial to prevent pathological hyperthermia. 26825461 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Although a group of patients exhibit episodic systemic inflammation (periodic fevers), these disorders are mediated by continuous overproduction and release of pro-inflammatory mediators, such as IL-1 and IL-6, and TNF and are best considered as autoinflammatory diseases rather than periodic fevers. 24831056 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Serum Th1/Th2 cytokine levels, including tumor necrosis factor, interleukin (IL)-2, IL-4, IL-6, IL-10, and interferon, were quantitatively determined by cytometric bead array technology in 480 cases (230 children) of children with hemopathy in the bone marrow inhibition phase with signs of infection, such as fever, and without, to establish baseline and affected levels for comparison with healthy control children. 25526183 2014