Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE The rapid increase of IL-1β production in the supernatants of the LPS-induced cells was significantly higher at the fourth and the twenty-fourth hours in febrile and complex febrile seizures, respectively. 22911481 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β is a major mediator of fever and systemic inflammation, and mononuclear cells from FMF patients release higher levels of IL-1β. 22406096 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human Mice lacking the Tak1 gene in brain endothelial cells showed a blunted fever response and reduced lethargy upon intravenous injection of the endogenous pyrogen IL-1β. 22143887 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Interleukin 1 (IL-1) is a 17 kDa protein highly conserved through evolution and is a key mediator of inflammation, fever and the acute-phase response. 20173777 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 are important for the synthesis of acute phase proteins, and it is a pyrogen cytokine that may cause fever. 20080142 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation phenotype BEFREE Our results indicate that certain haplotypes in the IL-1 gene complex and in IL18 and IL4 predict an altered likelihood of the development of fever after smallpox vaccination. 17570108 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype RGD In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. 16455768 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Differences between early presymptomatic infection and natural infection involved genes that regulate the induction of apoptosis through mitogen-activated protein (MAP) kinases and signaling pathways through the endogenous pyrogen IL-1beta, a major inducer of fever. 16988231 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-18 uniquely induces IFN-gamma from T lymphocytes and natural killer cells but does not cause fever, whereas fever is a prominent characteristic of IL-1 in humans and animals. 15161979 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human The role of circulating immune complexes and biocompatibility of staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome. 15384034 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. 11852909 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 mediates host defence responses to local and systemic disease and injury (e.g. fever, slow-wave sleep, appetite suppression and neuroendocrine responses) and to neuroinflammation and cell death in neurodegenerative conditions, such as stroke and head injury. 11137152 2000
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. 9952427 1999
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Now, in mice, we report the effect of AT2 gene disruption on the hyperthermia induced by immunological (interleukin-1 (IL-1) injection) and non-immunological (saline injection or cage switch) stress.2. 10066912 1999
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 beta-induced fever can be blocked by IL-1ra pretreatment. 9629236 1998
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE We conclude that IL-6 is formed in brain in response to both i.v. and i.c.v. pyrogens; however, its formation, whether requiring the prior induction of IL-1 or not, does not appear to be critical for the development of the fever. 9729338 1998
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation phenotype BEFREE Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever. 9049422 1997
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Thus, the results suggest that agonist occupancy of the type I IL-1 receptor is essential for IL-1 beta-mediated fever. 8830306 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE Freshly isolated leukemic cells from patients with adult T-cell leukemia (ATL) produce high levels of interleukin-1 (IL-1), which is believed to play an important role in neutrophilia, elevation of C-reactive protein, osteolytic bone lesions, hypercalcemia, and fever in ATL. 7628587 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE In this report, the effects of elevated temperature and dexamethasone on LPS-stimulated IL-1 beta and TNF alpha mRNA gene expression and protein synthesis were studied in human astrocytoma cell lines and primary cultures of human fetal astrocytes. 2022738 1991
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE These results support the hypothesis that elevated temperature is one of the physiologic signals for down-regulation of IL-1 beta biosynthesis through a mechanism related to the induction of hsp. 3139749 1988
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE ETAF/IL-1 has a multiplicity of divergent biological effects: enhancement of thymocyte proliferation, stimulation of cells in the hypothalamus to mediate fever, leukocyte chemotaxis, stimulation of hepatic synthesis of acute-phase proteins, augmentation of IL-2 production and keratinocyte proliferation. 2854717 1988
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Tumor necrosis factor shares with IL-1 many of the systemic and local effects of IL-1; these include fever, acute phase protein synthesis and sleep. 3127333 1987
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE These studies establish that the dominant pI 7 form of recombinant human IL-1 possesses immunological and inflammatory properties and acts on the central nervous system to produce fever. 3519678 1986