Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.060 | GeneticVariation | phenotype | BEFREE | Based on preliminary data by our group suggesting an upregulation of the mitogen-activated protein kinases (MAPKs) in human lymphocytes exposed to dabrafenib and trametinib, specifically elevated expression of phosphorylated JNK (p-JNK), p38 MAPK (p-p38 MAPK), and ERK5 (p-ERK5), we hypothesized that the mechanism of MAPK pathway activation with DT therapy is similar to that reported in patients with familial Mediterranean fever (FMF), a rare, inherited condition characterized by episodes of fever and rash that responds exceedingly well to colchicine-based therapy in which the MAPK pathway is hyper-activated. | 30767130 | 2019 | ||||
|
0.060 | Biomarker | phenotype | BEFREE | Further investigation of the molecular mechanisms revealed that FT-A treatment rapidly inhibited phosphorylation of extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 in both yeast induced pyrexia mice and HEK 293T-TRPV1 cells. | 28123347 | 2017 | ||||
|
0.060 | Biomarker | phenotype | BEFREE | While Aha1 is non-essential under standard growth conditions and at elevated temperature, Aha1 protects against ethanol stress. | 28455612 | 2017 | ||||
|
0.060 | PosttranslationalModification | phenotype | BEFREE | OZ pre-treatment decreased the expression of HT-induced Bcl-2 and increased the expression of pro-apoptotic Bax, while markedly suppressed the phosphorylation of JNK and p38. | 28111999 | 2017 | ||||
|
0.060 | AlteredExpression | phenotype | BEFREE | This is demonstrated by the ability of short term HT to prevent IL-1beta induced activation of MAPK p38 dependent, but NF-kappaB independent genes. | 19298849 | 2010 | ||||
|
0.060 | Biomarker | phenotype | BEFREE | We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever. | 15161979 | 2004 |