|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we report that fever promoted T lymphocyte trafficking through heat shock protein 90 (Hsp90)-induced α4 integrin activation and signaling in T cells.
|
30650373 |
2019 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recently, we have shown that Hsp90 is essential at elevated temperature in the aquatic model bacterium <i>Shewanella oneidensis</i>, and we have identified a client of Hsp90, TilS, involved in tRNA modification.
|
31088919 |
2019 |
|
HSP90AA1
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In vivo results using Hsp90 substitution mutants showed that several residues in this region were important or essential for growth at high temperature.
|
29463764 |
2018 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
During ethanol fermentation at high temperature (42°C), genes encoding heat shock proteins (ssq1 and hsp90), alcohol dehydrogenases (adh1, adh2, adh3 and adh4) and glyceraldehyde-3-phosphate dehydrogenase (tdh2) were up-regulated, suggesting that these genes might play a crucial role in the thermotolerance ability of P. kudriavzevii RZ8-1 under heat stress.
|
29154013 |
2018 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Several genes have recently been shown to affect the innate resistance of laboratory strains of Biomphalaria glabrata to infection with Schistosoma mansoni, including Hsp90, the expression of which following a brief exposure to elevated temperature can interfere with resistance in juvenile BS-90 snails.
|
29648939 |
2018 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results thus suggest that HSP90 inhibition can be a safe, simple and efficient approach to improving hyperthermia treatment efficacy and reducing thermotolerance, paving the way for <i>in vivo</i> studies.
|
29228626 |
2017 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HSP70 and HSP90 are highly expressed in Peloco and Caneluda within heat stress, these breeds proved to be very resistant to high temperature.
|
29020081 |
2017 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore, our study links the essentiality of bacterial Hsp90 at high temperature with the identification of a client.
|
28445720 |
2017 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus a combination of hyperthermia and inhibition of HSP90 might be a feasible therapeutic strategy for HCC.
|
27909289 |
2016 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hsp90 has been shown to (a) promote HIV-1 gene expression in acutely infected cells, (b) localize at the viral promoter DNA, (c) mediate enhanced replication in conditions of hyperthermia and (d) activate the P-TEFb complex, which is essential for efficient HIV-1 transcription.
|
25004926 |
2014 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity.
|
22807676 |
2012 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
By contrast, the HSP90 and HSP70/72/105 inhibitors had no effect on AMF expression and motility downregulated by hyperthermia.
|
23027359 |
2012 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The co-inhibition of HSP70/HSP90 synergistically sensitizes nasopharyngeal carcinoma cells to hyperthermia.
|
21498475 |
2012 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Elevated temperature relieves Hsp90-mediated repression of the morphogenetic program.
|
19327993 |
2009 |
|
HSP90AA1
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Resistance was abrogated by Hsp90 inhibitors and by febrile temperatures, suggesting new therapeutic strategies and a clinical benefit of fever.
|
16195452 |
2005 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These three hsp90 transcripts were constitutively expressed in porcine tissues including kidney, liver, brain, and heart, and their levels were markedly enhanced during recovery from 30-min hyperthermia treatment at 43 degrees C. Furthermore, we found that HSP90 was preferentially expressed in pituitary gland, brain, adrenal gland, and testis, in comparison to the other tissues.
|
9931505 |
1999 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The over expression of hsp90 and hsp70 in SLE is likely therefore to reflect cellular events resulting in the specific induction of these hsps rather than a generalized induction of all hsp synthesis due to the stress of the disease or the presence of fever.
|
1335295 |
1992 |