Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE Proinflammatory cytokines, tumor necrosis factor α, interleukin 1 (IL-1), IL-2, interferon γ (IFNγ), and macrophage chemoattractant protein 1 elicit fever, inflammation, multiple organ injury, hypotension, and lethal shock. 30909619 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE Histopathological examination showed induction of both apoptosis and necrosis and accumulation of CD8+ T-cells and macrophages/microglia accompanied by marked expressions of heat shock protein-70 (HSP70), which was not induced by mild hyperthermia alone at 45° C or an interleukin-2-mediated immune reaction. 30719212 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE The roles of interleukin-2 (IL-2) and interferon (IFN) α, β and γ in rescuing NK cells from hyperthermia and irradiation were studied. 29374687 2018
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE The most common grade 3-4 adverse events were hypersensitivity reactions (19 [10%] of 185 patients in the dinutuximab beta group vs 39 [20%] of 191 patients in the dinutuximab plus subcutaneous IL-2 group), capillary leak (five [4%] of 119 vs 19 [15%] of 125), fever (25 [14%] of 185 vs 76 [40%] of 190), infection (47 [25%] of 185 vs 64 [33%] of 191), immunotherapy-related pain (19 [16%] of 122 vs 32 [26%] of 124), and impaired general condition (30 [16%] of 185 vs 78 [41%] of 192). 30442501 2018
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2. 30193538 2018
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 AlteredExpression phenotype BEFREE Moreover, in these patients, the TNF-α, INF-γ, IL-2, and IL-6 levels were significantly (P < 0.001) different from patients who did not develop a fever. 28106314 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype CTD_human Consolidation biochemotherapy for patients with advanced nonsmall cell lung carcinoma responding to induction PVM (cisplatin, vinblastine, mitomycin-C) regimen. A phase II study. 8635092 1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 GeneticVariation phenotype BEFREE Constitutional symptoms (fever, malaise, and fatigue) and asymptomatic hyperbilirubinemia were the chief dose-limiting toxic effects of interleukin-2 therapy. 8857018 1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.380 Biomarker phenotype BEFREE Human peripheral blood T cells depleted of adherent cells underwent a blastogenic response and released interleukin 2 in the presence of hrIL-1 and mitogen. hrIL-1 was a potent inflammatory agent by its ability to induce human dermal fibroblast prostaglandin E2 production in vitro and to produce monophasic (endogenous pyrogen) fever when injected into rabbits or endotoxin-resistant mice. 3519678 1986