Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE Treatment with the highest dose of EA-230 resulted in a significant attenuation of the LPS-induced increase in plasma levels of inflammatory mediators interleukin (IL)-6, IL-8, IL-1 receptor antagonist, monocyte chemoattractant protein-1, macrophage inflammatory proteins-1α and -1β, and vascular cell adhesion protein-1 (% reduction of 48, 28, 33, 28, 14, 16 and 19 respectively, p < .01), and reduced fever (peak decrease from 1.8 ± 0.1°C to 1.3 ± 0.2°C, P < .05) and symptom scores (peak decrease from 7.4 ± 1.0 to 4.0 ± 1.2 points, P < .05). 30919998 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE PCT, IL-6, and IL-8 in HUCB predicted chorioamnionitis and fever in the delivering mother (89%, 83%, and 72%, respectively). 29563816 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE Both fever and the inflammatory mediators IL-6 and IL-8 were negatively associated with post-transfusion haemoglobin increment. 30159896 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE Here we found that FT-A exerted apparent antipyretic effect through decreasing the levels of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and interleukin 8 (IL-8) in a dose-dependent fashion on the yeast induced pyrexia mice. 28123347 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE Additionally, MAVS expression was increased and was required for IL-8 production upon CSFV infection. 29375538 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype BEFREE In active PTB, plasma IL-8/CXCL8 [median(IQR), 6.0(3.6-15.1) vs 3.6(3.6-3.6) pg/ml, P<0.001] and IL-6 were elevated, which significantly correlated with mycobacterial load, extent of lung consolidation (rs +0.509, P<0.001), severity-score (rs +0.317, P = 0.004), and fever and hospitalization durations (rs +0.407, P<0.001).IL-18 and sTNFR1 also increased. 27434276 2016
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 AlteredExpression phenotype BEFREE Exposure to hyperthermia reduces IL-1beta-induced prostaglandin E2 release, suppresses activation of the adhesion molecules VCAM-1, ICAM-1, the cytokines TNFalpha, IL-1alpha, IL-1beta, IL-8 as well as COX-2 protein synthesis. 16955275 2006
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.370 Biomarker phenotype CTD_human Only dipyrone inhibited IL-8, PFPF or PGF2alpha fever. 11852909 2002