Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Tumor repressor p53 is required for heat-induced apoptosis at hyperthermia conditions (>41°C). 31825845 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE As a proof of concept, we have shown that enhanced p53 expression in monocytes attenuated Plasmodium-induced inflammation and predicted protection from fever. 31492649 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE Collectively, these findings indicate that miR-34a may serve an important role in hyperthermia-regulated apoptosis and proliferation in HCT116 cells by influencing the transcriptional activity of p53. 29285066 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Neither DA specific p53 deletion nor p53 pharmacological inhibition affected hyperthermia induced by MA binge. 28342134 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia. 22331493 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Our results indicate that TP53 is a predominant target of chronic hyperthermia in the development of Kangri cancer in the moderate risk Kashmiri population. 19486858 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE In addition, the level of p53 after the combination treatment was only slightly increased in comparison with hyperthermia alone. 18425350 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE In this study, attention was focused on p53 as a possible predictive indicator for the efficacy of hyperthermic cancer therapy. 19065343 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Pathways of signaling by S100A4, by its interaction with and sequestration of p53, and by Notch also seem differentially operational in the induction of apoptosis, and both appear to be activated as alternative pathways in the context of hyperthermia signaling independently of p53. 17497677 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE The combined therapy of hyperthermia, with chemotherapy, and/or irradiation showed a greater effect on down-regulating the expression of p53 (0.208 +/- 0.009 vs 0.155 +/- 0.0115, P < 0.01) and Bcl-2 (0.086 +/- 0.010 vs 0.026 +/- 0.0170, P < 0.01) and up-regulating Bax expression (0.091 +/- 0.0013 vs 0.207 +/- 0.027, P < 0.01) compared with any single therapy. 17708613 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Taken together, the findings showed that combining adenoviral p53 transfer with mild hyperthermia inhibits the proliferation of malignant glioma cells in an additive manner, irrespective of their endogenous p53 status, suggesting a novel treatment strategy for this malignancy. 16278167 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE In conclusion, Adp53 combined with hyperthermia was safe and effective in patients with advanced cancer and p53 gene therapy was potential to thermosensitize in advanced cancer. 16304714 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE These findings strongly imply that p53 status is a useful candidate for a predictive indicator of the effectiveness in hyperthermic therapy. 14744533 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Mitomycin C did not affect the accumulation of Hsp72 induced by hyperthermia in H1299 cells regardless of their p53 gene status. 15183489 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations. 15380594 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status. 12708486 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation phenotype BEFREE Although difficult because of the documented coexposure to various life style risk factors in most patients of this series, the hypothesis is proposed that besides smoking and alcohol drinking the commonly consumed hot mate tea in this high risk area for ESCC is responsible for this different pattern of TP53 mutations because of chronic hyperthermic irritation and inflammation in the esophagus with an endogenous formation of radicals or carcinogenic factors that lead to a higher prevalence of transition mutations. 11857392 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE We investigated, therefore, the effect of hyperthermic exposures on the levels and DNA-binding activity of p53. 11857452 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 AlteredExpression phenotype BEFREE On the other hand, the accumulation of p27 by hyperthermia was not seen in A-172 or U251 cells, and the exogenous expression of p53 did not affect the accumulation of p27 by hyperthermia in U251 cells. 11719966 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation phenotype BEFREE By employing LN382 glioma cell that has a temperature-sensitive p53 mutation, we found that the activation of p53 prevents hyperploid formation after the prolonged nocodazole treatment. 11313973 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 GeneticVariation phenotype BEFREE In this study, a novel approach was evaluated of combining Ad5CMV-p53 gene therapy with hyperthermia (HT), in the CNE-1 NPC cell line, which harbours a mutation in codon 249 of the p53 gene. 11212879 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE These results indicate that Adv-mediated transduction of p53 would render glioma cells highly sensitive to hyperthermia. 11380242 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype BEFREE To clarify the role of the p53 gene and apoptosis in combined hyperthermia, chemotherapy and radiation (hyperthermochemoradiotherapy, HCR therapy) for rectal cancer, we examined the histological response, rate of apoptosis, DNA fragmentation and p53 status in tumours from 28 patients undergoing HCR therapy before surgery and from 22 patients who did not have preoperative treatment. 9459162 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.200 Biomarker phenotype HPO