Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9536
Gene Symbol: PTGES
PTGES
0.340 Biomarker phenotype BEFREE These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E<sub>2</sub> in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions. 31508540 2019
Entrez Id: 9536
Gene Symbol: PTGES
PTGES
0.340 Biomarker phenotype BEFREE In conclusion, our in silico approach leads to the selection of a compound that presents the chemical features to inhibit mPGES-1 and reduces fever induced by LPS. 28390086 2017
Entrez Id: 9536
Gene Symbol: PTGES
PTGES
0.340 Biomarker phenotype BEFREE Furthermore, injection of a virus vector expressing microsomal prostaglandin E synthase-1 (mPGES-1) into the median preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in response to LPS. 28438967 2017
Entrez Id: 9536
Gene Symbol: PTGES
PTGES
0.340 Biomarker phenotype CTD_human The febrile response is triggered by prostaglandin E2 synthesis mediated by induced expression of the enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1). 25164664 2014
Entrez Id: 9536
Gene Symbol: PTGES
PTGES
0.340 Biomarker phenotype BEFREE Studies, mainly from disruption of the mPGES-1 gene in mice, indicate key roles of mPGES-1-generated PGE(2) in female reproduction and in pathological conditions such as inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. 17878511 2007