Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE Circulating plasma levels of Act A or BMP4 are similar in controls compared to FOP patients, and suggest the potential for an autocrine or paracrine route for pathological signaling. 29170109 2018
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 Biomarker disease BEFREE We found that FOP iECs could form in conditions with low or absent BMP4. 27530160 2016
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE In one model, BMP4 is over-expressed under the control of the neuron-specific enolase promoter; the second model is a knock-in of a recurrent FOP mutation of ACVR1/ALK2. 22736080 2012
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 Biomarker disease BEFREE Interestingly, both recombinant human BMP4 induction in an animal model and the dysregulated BMP signaling pathway in a patient with fibrodysplasia ossificans progressiva were sufficient to recruit at least two populations of cells, one of hematopoietic origin and at least one of non-hematopoietic origin, that contribute to the formation of an ectopic skeleton. 17272450 2007
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE Our data suggest that dysregulated expression of BMP4 and BMP5 genes is associated with an array of human axial skeletal abnormalities similar to the short ear mouse and FOP. 17345627 2007
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE Whereas the primary genetic defect in this condition is unknown, BMP4 mRNA and protein and BMP receptor type IA (BMPRIA) protein are overexpressed in cultured lymphocytes from FOP patients, supporting that altered BMP signaling is involved in this disease. 16753021 2006
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE In the absence of exogenous BMP-4 stimulation (basal state), steady-state levels of all of the BMP antagonists that were investigated were similar in fibrodysplasia ossificans progressiva and control cell lines. 12672843 2003
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE These data exonerate NF-kappaB as the critical molecular and genetic pathogenic mediator in fibrodysplasia ossificans progressiva and, therefore, implicate a defect in another regulatory pathway as the cause for bone morphogenetic protein-4 overexpression in the disease. 12579020 2003
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE Although elevated levels of bone morphogenetic protein 4 (BMP4) occur in lymphoblastoid cells and in lesional cells of patients with FOP, mutations have not been identified in the BMP4 gene, suggesting that the mutation in FOP may reside in a BMP4-interacting factor or in another component of the BMP4 pathway. 11076054 2000
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 GeneticVariation disease BEFREE Within the less severely affected family, affected and unaffected members showed similar levels of mRNA expression of BMPs 1, 2, 4, and 5, and linkage of FOP to the BMP-4 gene was excluded. 10441661 1999
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE In contrast, early fibrodysplasia ossificans progressiva lesions express abundant bone morphogenetic protein 4, without abundant expression of c-Fos, suggesting that the primary molecular defect in fibrodysplasia ossificans progressiva may be independent of the sustained Fos effects on chondrogenesis and osteogenesis. 9577414 1998
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 Biomarker disease BEFREE The presence of bone morphogenetic protein 4 receptor messenger ribonucleic acid in fibrodysplasia ossificans progressiva lesional tissue and unaffected muscle tissue and demonstrates the deregulation of bone morphogenetic protein 4 messenger ribonucleic acid in fibrodysplasia ossificans progressiva. 9577408 1998
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 GeneticVariation disease BEFREE Although this study has not identified any mutations in the bone morphogenetic protein 4 gene that are correlated with the occurrence of fibrodysplasia ossificans progressiva, the bone morphogenetic protein 4 gene cannot yet be excluded from consideration as the genetic cause of this disorder because a mutation could be present in unexamined regulatory sequences of this gene. 9577410 1998
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 AlteredExpression disease BEFREE Bone morphogenetic protein 4 (BMP-4) is a vital regulatory molecule that functions throughout human development in mesoderm induction, tooth development, limb formation, bone induction, and fracture repair and is overexpressed in patients who have fibrodysplasia ossificans progressiva. 9701626 1998
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 Biomarker disease BEFREE Bone morphogenetic protein 4 and its mRNA were detected in the lymphoblastoid cell lines from a man with fibrodysplasia ossificans progressiva and his three affected children (two girls and a boy), but not from the children's unaffected mother. 8678932 1996
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.300 Biomarker disease MGD