Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.330 Biomarker disease BEFREE To assess the clinical value and specificity of the BCOR internal tandem duplication, a group of 11 ETV6-rearranged congenital infantile fibrosarcomas were evaluated and no BCOR internal tandem duplication was identified in any case. 28256570 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.330 GeneticVariation disease BEFREE The fusion transcript identified encompasses exon 4 of ETV6 and exon 14 of NTRK3 and therefore differs from the canonical ETV6-NTRK3 chimera of infantile fibrosarcomas. 26606880 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.330 GeneticVariation disease BEFREE ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. 11743047 2001
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.330 FusionGene disease ORPHANET
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.320 Biomarker disease BEFREE In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. 30520818 2019
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.320 Biomarker disease BEFREE The fusion transcript identified encompasses exon 4 of ETV6 and exon 14 of NTRK3 and therefore differs from the canonical ETV6-NTRK3 chimera of infantile fibrosarcomas. 26606880 2016
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3
0.320 FusionGene disease ORPHANET
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.300 Biomarker disease CTD_human Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. 20601955 2010
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.130 Biomarker disease BEFREE We suggest that uterine sarcomas with a morphology resembling fibrosarcoma (and in which leiomyosarcoma and the known molecularly confirmed high-grade endometrial stromal sarcomas have been excluded) can be divided into 3 groups:- an NTRK fusion group, a COL1A1-PDGFB fusion group and a group containing neither of these molecular abnormalities which, on the basis of positive staining with S100, could be tentatively classified as malignant peripheral nerve sheath tumor, although additional molecular studies may identify specific genetic alterations necessitating a nomenclature change. 30877273 2019
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.130 GeneticVariation disease BEFREE Recently, the COL1A1-PDGFB chimeric gene resulting from a reciprocal translocation, t(17;22), and/or a supernumerary ring chromosome, r(17;22), has been identified, not only in conventional dermatofibrosarcoma protuberans (DFSP) but also in areas of DFSP with progression to fibrosarcoma (so-called fibrosarcomatous transformation) (FS-DFSP). 11329146 2001
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.130 Biomarker disease BEFREE In sample of DFSP with fibrosarcomatous transformation, the COL1A1-PDGFB could not be detected in the fibrosarcoma areas of the third recurrence, though the chimeric transcripts were identified in the ordinary DFSP areas of the first recurrence. 10565681 1999
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.130 Biomarker disease HPO
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
0.120 Biomarker disease BEFREE We suggest that uterine sarcomas with a morphology resembling fibrosarcoma (and in which leiomyosarcoma and the known molecularly confirmed high-grade endometrial stromal sarcomas have been excluded) can be divided into 3 groups:- an NTRK fusion group, a COL1A1-PDGFB fusion group and a group containing neither of these molecular abnormalities which, on the basis of positive staining with S100, could be tentatively classified as malignant peripheral nerve sheath tumor, although additional molecular studies may identify specific genetic alterations necessitating a nomenclature change. 30877273 2019
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
0.120 GeneticVariation disease BEFREE Recently, the COL1A1-PDGFB chimeric gene resulting from a reciprocal translocation, t(17;22), and/or a supernumerary ring chromosome, r(17;22), has been identified, not only in conventional dermatofibrosarcoma protuberans (DFSP) but also in areas of DFSP with progression to fibrosarcoma (so-called fibrosarcomatous transformation) (FS-DFSP). 11329146 2001
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
0.120 Biomarker disease HPO
Entrez Id: 4507
Gene Symbol: MTAP
MTAP
0.110 Biomarker disease BEFREE These compounds were also examined for growth inhibition of isogenic MTAP(+) and MTAP(-) HT1080 fibrosarcoma cells, and 4 of the 5 compounds exhibited evidence of modest but significant increased potency in MTAP(-) cells. 21131597 2011
Entrez Id: 4507
Gene Symbol: MTAP
MTAP
0.110 Biomarker disease HPO
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE Expression of T1<sup>Pr αMT1</sup> brings about a complete abrogation of the gelatinolytic activity of cellular MT1-MMP in HT1080 fibrosarcoma cells whilst in renal carcinoma cells CaKi-1, the GPI-TIMP causes a disruption in MMP-mediated proteolysis of ECM components such as fibronectin, collagen I and laminin that consequently triggers a downstream senescence response. 30641935 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression disease BEFREE CSE positively regulated the expression of VEGF and increased the levels of certain key proteins in the VEGF pathway, including the phosphoinositide (PI3K)/protein kinase B (AKT) pathway [PI3K, Akt and phosphorylated (p)Akt], focal adhesion kinase (FAK)‑paxillin pathway (FAK and paxillin) and rat sarcoma (Ras)‑mitogen‑activated protein kinase pathway [Ras, rapidly accelerated fibrosarcoma, extracellular signal‑regulated kinase (ERK)1/2 and pERK1/2]. 31173185 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE The current study investigated the ability of two secoiridoids, GL-3 (<b>1</b>) and oleonuezhenide (<b>2</b>), isolated from the fruits of <i>Ligustrum japonicum</i> to inhibit MMP-2 and -9 activity in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 human fibrosarcoma cells. 30744075 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression. 29518973 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. 30519264 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 Biomarker disease BEFREE The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression. 29518973 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Here, we report that Gd@C<sub>82</sub>(OH)<sub>22</sub> promote the binding activity of tumor necrosis factor (TNFα) to tumor necrosis factor receptors 2 (TNFR2), activate TNFR2/p38 MAPK signaling pathway to increase cellular collagen expression in fibrosarcoma cells and human primary lung cancer associated fibroblasts isolated from patients. 29080421 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.100 Biomarker disease BEFREE Endothelial and fibrosarcoma cells showed similarly strong adhesion profiles with marked enhancer effect by fibronectin. 28493851 2017