Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.330 Biomarker group CTD_human Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice. 21297660 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.330 PosttranslationalModification group BEFREE Because genetic and epigenetic alterations of the adenomatous polyposis coli (APC) gene are common events in gastrointestinal tumor development, we sought to investigate the frequency and level of aberrant APC promoter methylation in primary tumors and paired preoperative serum or plasma samples of lung cancer patients by semiquantitative methylation-specific fluorogenic real-time PCR. 11809682 2002
Entrez Id: 324
Gene Symbol: APC
APC
0.330 GeneticVariation group BEFREE The mutated genes with positive or negative roles in cell growth or survival in aneuploid gastrointestinal cancer (e.g., APC, K-ras, and p53) are less frequently mutated in near-diploid MMP gastrointestinal tumors. 10383166 1999
Entrez Id: 324
Gene Symbol: APC
APC
0.330 GeneticVariation group BEFREE Established MSH6-null mice present a frequent occurrence of gastrointestinal tumors without microsatellite instability (MI), suggesting the possibility of the APC gene being a mutational target. 9808525 1998
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.320 Biomarker group BEFREE Examples of these molecularly targeted biomarker therapies are: tyrosine kinase inhibitors in chronic myeloid leukemia and gastrointestinal tumors; anaplastic lymphoma kinase (ALK) inhibitors in lung cancer with EML4-ALk fusion; HER2/neu blockage in HER2/neu-positive breast cancer; and epidermal growth factor receptors (EGFR) inhibition in EGFR-mutated lung cancer. 25468140 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.320 Biomarker group CTD_human HER2 Testing in Gastric/Gastroesophageal Junction Adenocarcinomas: Unique Features of a Familiar Test. 21673877 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.320 AlteredExpression group BEFREE Flow cytometric and immunoblotting analyses demonstrated that GLA treatment substantially reduced Her-2/neu protein levels in the Her-2/neu-overexpressing cell lines BT-474, SK-Br3, and MDA-MB-453 (breast cancer), SK-OV3 (ovarian cancer), and NCI-N87 (gastrointestinal tumor derived). 16264182 2005
Entrez Id: 9518
Gene Symbol: GDF15
GDF15
0.300 Therapeutic group CTD_human Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. 24440808 2014
Entrez Id: 3090
Gene Symbol: HIC1
HIC1
0.300 Biomarker group CTD_human Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice. 21297660 2011
Entrez Id: 641
Gene Symbol: BLM
BLM
0.110 GeneticVariation group BEFREE Mutational studies of 57 sporadic gastrointestinal tumor DNAs revealed the presence of length variations in three of them: (a) BLM; (b) CBL; and (c) HOXA1. 9731483 1998
Entrez Id: 641
Gene Symbol: BLM
BLM
0.110 Biomarker group HPO
Entrez Id: 6391
Gene Symbol: SDHC
SDHC
0.100 Biomarker group HPO
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group HPO
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
0.100 Biomarker group HPO
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.040 Biomarker group BEFREE In fact, the core effectors YAP/TAZ in Hippo signalling pathway cooperate with β-catenin in Wnt signalling pathway to promote GI neoplasia. 31342636 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.040 Biomarker group BEFREE Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth. 27507810 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.040 Biomarker group BEFREE Acquired resistance to epidermal growth factor receptor (EGFR) targeted antibodies represents a clinical challenge in the treatment of gastrointestinal tumors such as metastatic colorectal cancer, but its molecular mechanisms are incompletely understood. 26059438 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.040 Biomarker group BEFREE Whereas all the Apc1638N;Ctnnb1(+/+) mice developed gastrointestinal tumors, none were present in the Apc1638N;Ctnnb1(-/+) mice. 23045279 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.040 PosttranslationalModification group BEFREE Mutations of the epidermal growth factor receptor gene in gastrointestinal tract tumor cell lines. 16596188 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.040 GeneticVariation group BEFREE The presence of activating mutations within EGFR in both esophageal and pancreatic adenocarcinomas defines a previously unrecognized subset of gastrointestinal tumors in which EGFR signaling may play an important biological role. 16857803 2006
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.040 AlteredExpression group BEFREE Our results demonstrate a novel mechanism for activation of beta-catenin in gastrointestinal tumors and support the concept that overexpression of p73 isoforms can play an important role in tumorigenesis. 15374945 2004
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.040 AlteredExpression group BEFREE Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. 12952568 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.030 AlteredExpression group BEFREE Agents that inhibit AURKA might slow the growth of gastrointestinal tumors with activation of KRAS. 30342037 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.030 Biomarker group BEFREE Mutation in K-RAS (K-RAS-MT) plays important roles in both cancer progression and resistance to anti-epidermal growth factor receptor (EGFR) therapy in gastrointestinal tumors. 27312358 2017
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.030 Biomarker group BEFREE Examples of these molecularly targeted biomarker therapies are: tyrosine kinase inhibitors in chronic myeloid leukemia and gastrointestinal tumors; anaplastic lymphoma kinase (ALK) inhibitors in lung cancer with EML4-ALk fusion; HER2/neu blockage in HER2/neu-positive breast cancer; and epidermal growth factor receptors (EGFR) inhibition in EGFR-mutated lung cancer. 25468140 2015