| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | GeneticVariation | disease | BEFREE | A meta-analysis was applied to calculate the pooled odds-ratio and 95% confidence intervals (CIs) to evaluate the association between TLR4 polymorphism and glaucoma. | 30877182 | 2019 | ||||
|
0.060 | Biomarker | disease | BEFREE | In the present review, 22 loci of glaucoma are presented, including the relevant genes (myocilin, interleukin 20 receptor subunit B, optineurin, ankyrin repeat‑ and SOCS box‑containing protein 10, WD repeat‑containing protein 36, EGF‑containing fibulin‑like extracellular matrix protein 1, neurotrophin 4, TANK‑binding kinase 1, cytochrome P450 subfamily I polypeptide 1, latent transforming growth factor β binding protein 2 and TEK tyrosine kinase endothelial) and 74 other genes (including toll‑like receptor 4, sine oculis homeobox Drosophila homolog of 1, doublecortin‑like kinase 1, RE repeats‑encoding gene, retinitis pigmentosa GTPase regulator‑interacting protein, lysyl oxidase‑like protein 1, heat‑shock 70‑kDa protein 1A, baculoviral IAP repeat‑containing protein 6, 5,10‑methylenetetrahydrofolate reductase and nitric oxide synthase 3 and nanophthalmos 1) that are more closely associated with glaucoma. | 29845210 | 2018 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | Comparing cases to controls as regards co-morbidity with other systemic diseases, there were no statistically significant differences between groups in all assessed diseases except for a family history of glaucoma (p = 0.014) Conclusions: In conclusion, we could not detect any direct link between genotypes or allele frequencies of SNP rs4986790 in the TLR4 gene and POAG. | 27064537 | 2017 | ||||
|
0.060 | Biomarker | disease | BEFREE | Our findings support the role of TLR4 in the pathophysiology of glaucoma. | 28214954 | 2017 | ||||
|
0.060 | Biomarker | disease | BEFREE | The allele frequencies of the 5 TLR4 SNPs were higher in all of the glaucoma groups than that in the control group. | 22831837 | 2012 | ||||
|
0.060 | Biomarker | disease | LHGDN | Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. | 18586872 | 2008 |