Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1109
Gene Symbol: AKR1C4
AKR1C4 		0.010 GeneticVariation disease BEFREE <b>Abbreviations</b>: BCVA: best corrected visual acuity; BMI: body mass index; CDR: cup-to-disc ratio; EDTA: ethylenediaminetetraacetic acid; ELISA: enzyme-linked immunosorbent assay; ESR: erythrocyte sedimentation rate; HVF: Humphrey visual field; IOP: intraocular pressure; KPro G: keratoprosthesis with glaucoma; KPro NoG: keratoprosthesis without glaucoma; KPro: keratoprosthesis; MD: mean deviation; NA: narrow angle; non-KPro: without keratoprosthesis; PACG: primary angle closure glaucoma; RNFL: retinal nerve fiber layer; TNF-α: tumor necrosis factor alpha; TNFR1: tumor necrosis factor receptor 1; TNFR2: tumor necrosis factor receptor 2. 30632412 2019
Entrez Id: 1038
Gene Symbol: CDR1
CDR1 		0.010 GeneticVariation disease BEFREE <b>Abbreviations</b>: BCVA: best corrected visual acuity; BMI: body mass index; CDR: cup-to-disc ratio; EDTA: ethylenediaminetetraacetic acid; ELISA: enzyme-linked immunosorbent assay; ESR: erythrocyte sedimentation rate; HVF: Humphrey visual field; IOP: intraocular pressure; KPro G: keratoprosthesis with glaucoma; KPro NoG: keratoprosthesis without glaucoma; KPro: keratoprosthesis; MD: mean deviation; NA: narrow angle; non-KPro: without keratoprosthesis; PACG: primary angle closure glaucoma; RNFL: retinal nerve fiber layer; TNF-α: tumor necrosis factor alpha; TNFR1: tumor necrosis factor receptor 1; TNFR2: tumor necrosis factor receptor 2. 30632412 2019
Entrez Id: 862
Gene Symbol: RUNX1T1
RUNX1T1 		0.010 GeneticVariation disease BEFREE <b>Abbreviations</b>: BCVA: best corrected visual acuity; BMI: body mass index; CDR: cup-to-disc ratio; EDTA: ethylenediaminetetraacetic acid; ELISA: enzyme-linked immunosorbent assay; ESR: erythrocyte sedimentation rate; HVF: Humphrey visual field; IOP: intraocular pressure; KPro G: keratoprosthesis with glaucoma; KPro NoG: keratoprosthesis without glaucoma; KPro: keratoprosthesis; MD: mean deviation; NA: narrow angle; non-KPro: without keratoprosthesis; PACG: primary angle closure glaucoma; RNFL: retinal nerve fiber layer; TNF-α: tumor necrosis factor alpha; TNFR1: tumor necrosis factor receptor 1; TNFR2: tumor necrosis factor receptor 2. 30632412 2019
Entrez Id: 10954
Gene Symbol: PDIA5
PDIA5 		0.010 GeneticVariation disease BEFREE 278 patients with POAG, 132 patients with primary angle closure glaucoma (PACG) and 135 patients with pseudoexfoliative glaucoma (PEXG) were genotyped for single nucleotide polymorphisms (SNPs) rs11720822 in PDIA5 and 471 POAG, 184 PACG and 218 PEXG patients were genotyped for rs2754511 in BIRC6. 25118708 2014
Entrez Id: 5879
Gene Symbol: RAC1
RAC1 		0.010 GeneticVariation disease BEFREE Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. 29016860 2017
Entrez Id: 998
Gene Symbol: CDC42
CDC42 		0.010 GeneticVariation disease BEFREE Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. 29016860 2017
Entrez Id: 3082
Gene Symbol: HGF
HGF 		0.040 GeneticVariation disease BEFREE Hepatocyte growth factor genetic variations and primary angle-closure glaucoma in the Han Chinese population. 23585864 2013
Entrez Id: 10057
Gene Symbol: ABCC5
ABCC5 		0.020 Biomarker disease BEFREE ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. 24603532 2014
Entrez Id: 144100
Gene Symbol: PLEKHA7
PLEKHA7 		0.200 GeneticVariation disease BEFREE PLEKHA7 and COL11A1 were genotyped for single-nucleotide polymorphisms (SNPs) to investigate the possible association of these two genes with primary angle-closure glaucoma (PACG) and disease severity. 30809385 2019
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.010 GeneticVariation disease BEFREE A catalase promoter variant rs1001179 is associated with visual acuity but not with primary angle closure glaucoma in Saudi patients. 23961996 2013
Entrez Id: 11081
Gene Symbol: KERA
KERA 		0.010 GeneticVariation disease BEFREE A Novel KERA Mutation in a Case of Autosomal Recessive Cornea Plana With Primary Angle-Closure Glaucoma. 25967529 2016
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2 		0.020 Biomarker disease BEFREE A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control. 31725165 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.010 Biomarker disease BEFREE A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control. 31725165 2019
Entrez Id: 4015
Gene Symbol: LOX
LOX 		0.010 Biomarker disease BEFREE A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control. 31725165 2019
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.010 Biomarker disease BEFREE A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control. 31725165 2019
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1 		0.010 Biomarker disease BEFREE A significant increase was observed in the transcripts of MCP-1, TGF-β2, and SPARC in POAG and PACG (P < 0.05); CTGF, TGF-β1, LOX, LOXL2, ELN, COL1A1, and α-SMA in PACG (P < 0.05) compared with control. 31725165 2019
Entrez Id: 4907
Gene Symbol: NT5E
NT5E 		0.010 GeneticVariation disease BEFREE A total of 1778 subjects were recruited from the Eye & ENT Hospital of Fudan University from January 2010 to December 2015, including patients with PACG (male=296; female=569) and control subjects (male=290; female=623). 29102986 2017
Entrez Id: 55248
Gene Symbol: PACC1
PACC1 		0.040 GeneticVariation disease BEFREE Among the three studied SNPs, significant genetic association was identified for rs1015213 in the PAC/PACG (P = 0.002) and any-angle closure (P = 0.003) analyses. 23847314 2013
Entrez Id: 718
Gene Symbol: C3
C3 		0.010 Biomarker disease BEFREE Association of Plasma Complement C3 Levels With Primary Angle-Closure Glaucoma in Older Women. 28134964 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.010 AlteredExpression disease BEFREE Biometric parameters can combine with iris gene expression to more accurately define PACG from POAG. 26988898 2016
Entrez Id: 1301
Gene Symbol: COL11A1
COL11A1 		0.200 Biomarker disease BEFREE Both COL11A1 and PLEKHA7 were shown to confer significant risk for acute PAC/PACG. 24854855 2014
Entrez Id: 144100
Gene Symbol: PLEKHA7
PLEKHA7 		0.200 Biomarker disease BEFREE Both COL11A1 and PLEKHA7 were shown to confer significant risk for acute PAC/PACG. 24854855 2014
Entrez Id: 3791
Gene Symbol: KDR
KDR 		0.010 AlteredExpression disease BEFREE COL1A1, VEGFB, VEGFC and VEGFR2 mRNA expression was higher in PACG compared to POAG irises. 26988898 2016
Entrez Id: 4968
Gene Symbol: OGG1
OGG1 		0.010 Biomarker disease BEFREE Common polymorphisms of the <i>hOGG1, APE1</i> and <i>XRCC1</i> genes correlate with the susceptibility and clinicopathological features of primary angle-closure glaucoma. 28396513 2017
Entrez Id: 10133
Gene Symbol: OPTN
OPTN 		0.010 GeneticVariation disease BEFREE Exome sequencing identified 19 mutations (6 in MYOC, 9 in WDR36, 3 in OPA1, and 1 in OPTN) in 20 of 257 patients, including 4 patients with JOAG, 8 patients with POAG, and 8 patients with PACG. 24825108 2014