Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 28
Gene Symbol: ABO
ABO 		0.020 Biomarker disease BEFREE The HLA and ABO antigens in pigment dispersion syndrome. 655215 1978
Entrez Id: 28
Gene Symbol: ABO
ABO 		0.020 Biomarker disease BEFREE No associations between OAG and the ABO or Rh blood groups were seen. 8573026 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.020 GeneticVariation disease LHGDN Angiotensin-converting enzyme insertion-deletion polymorphism in primary open-angle glaucoma. 15564761 2005
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.020 GeneticVariation disease LHGDN Associations between the deletion polymorphism of the angiotensin 1-converting enzyme gene and ocular signs of primary open-angle glaucoma. 15864617 2005
Entrez Id: 55289
Gene Symbol: ACOXL
ACOXL 		0.100 GeneticVariation disease GWASCAT A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. 29891935 2018
Entrez Id: 170690
Gene Symbol: ADAMTS16
ADAMTS16 		0.100 GeneticVariation disease GWASDB Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. 22428042 2012
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1 		0.010 GeneticVariation disease LHGDN Certain polymorphisms of the ADRB1 and ADRB2 genes influence the pathophysiology of OAG in Japanese patients. 16785856 2006
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1 		0.010 GeneticVariation disease BEFREE Certain polymorphisms of the ADRB1 and ADRB2 genes influence the pathophysiology of OAG in Japanese patients. 16785856 2006
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.020 GeneticVariation disease LHGDN The IOP at diagnosis was significantly higher in OAG patients carrying 27Glu in the ADRB2 gene than in patients without this allele (p<0.001). 16785856 2006
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.020 Biomarker disease BEFREE Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma. 29483909 2018
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.020 GeneticVariation disease BEFREE Certain polymorphisms of the ADRB1 and ADRB2 genes influence the pathophysiology of OAG in Japanese patients. 16785856 2006
Entrez Id: 60312
Gene Symbol: AFAP1
AFAP1 		0.100 GeneticVariation disease GWASCAT Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. 25173105 2014
Entrez Id: 60312
Gene Symbol: AFAP1
AFAP1 		0.100 GeneticVariation disease GWASCAT A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. 29891935 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.010 GeneticVariation disease BEFREE Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. 15914614 2005
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1 		0.010 Biomarker disease BEFREE Alpha 2-adrenergic receptor (α2-ADR) agonists are used clinically for a range of indications including reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. 30198788 2019
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1 		0.100 GeneticVariation disease GWASCAT A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. 29891935 2018
Entrez Id: 56172
Gene Symbol: ANKH
ANKH 		0.100 GeneticVariation disease GWASCAT A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. 29891935 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 GeneticVariation disease LHGDN Single-nucleotide polymorphisms and glaucoma severity. 12817590 2003
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 GeneticVariation disease LHGDN Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. 11992263 2002
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 GeneticVariation disease LHGDN Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma. 15525904 2004
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 Biomarker disease BEFREE Further studies in the other ethnic populations should be performed to elucidate the relationship between APOE and OAG. 16110302 2005
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 GeneticVariation disease LHGDN The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma. 14769603 2004
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 GeneticVariation disease LHGDN Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. 17524782 2007
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.070 Biomarker disease BEFREE In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases. 16564058 2006
Entrez Id: 23365
Gene Symbol: ARHGEF12
ARHGEF12 		0.100 GeneticVariation disease GWASCAT A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. 29891935 2018