Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease UNIPROT
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease MGD
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
0.400 CausalMutation disease CGI
Entrez Id: 1616
Gene Symbol: DAXX
DAXX
0.330 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.200 GeneticVariation disease CLINVAR
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.190 CausalMutation disease CLINVAR
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
0.140 CausalMutation disease CLINVAR
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
0.120 GeneticVariation disease CLINVAR
Entrez Id: 160140
Gene Symbol: C11orf65
C11orf65
0.100 GeneticVariation disease CLINVAR
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE In situ analysis of tumour specimens undergoing neovascularization show that the production of VEGF is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci (presumably hypoxic regions) and the clustering of capillaries alongside VEGF-producing cells. 1279431 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE We observed EGFR gene amplification in astrocytomas and anaplastic astrocytomas with approximately the same incidence as in glioblastoma multiforme (33%), although large amplifications were only seen in glioblastoma multiforme. 1311022 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE A subpopulation of cells were present in the low-grade tumours that contained the same p53 gene mutation predominant in the cells of the recurrent tumours that had progressed to glioblastoma. 1311419 1992
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.100 AlteredExpression disease BEFREE Unlike GM-CSF, transforming growth factor-beta 2 mRNA is expressed in ex vivo tested glioblastoma tissues. 1315829 1992
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.100 Biomarker disease BEFREE However, there is no evidence for GM-CSF production by glioblastoma cells in vivo: fresh tumor samples lack the mRNA for GM-CSF and the protein is not detectable in the tumor cyst fluids or the cerebrospinal fluids of glioblastoma patients. 1315829 1992
Entrez Id: 5154
Gene Symbol: PDGFA
PDGFA
0.030 AlteredExpression disease BEFREE The PDGF A-chain mRNA was predominantly found in cell-rich areas in glioblastomas. 1317261 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Moreover, the presence of 15 cases of glioblastoma with loss of chromosome 10 but without EGFR gene amplification may further imply that the loss of a tumor suppressor gene (or genes) on chromosome 10 precedes EGFR gene amplification in glioblastoma tumorigenesis. 1320666 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Our findings suggest that the amplification and/or overexpression either of EGFR or of the alpha PDGFR along with the coordinate overexpression of the beta PDGFR can contribute to the malignant phenotype of distinct subsets of human glioblastoma. 1322795 1992
Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
0.090 AlteredExpression disease BEFREE In experiments to identify molecules that might be important in the pathogenesis of glioblastoma multiforme, the most common malignant brain tumor, we found that annexin II (Lipocortin 2, p36), a likely second messenger in several different mitogenic pathways, was highly expressed in tumor tissue of glioblastoma multiforme (9 of 9) and highly anaplastic astrocytoma (2 of 6), but not in astrocytomas of lower pathological grade (0 of 6). 1333884 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The more malignant histological features of anaplastic astrocytoma and glioblastoma multiforme appear to be reflected by a greater incidence of p53 accumulation. 1336544 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The loss of sequences on chromosome 10 and the deletions of 9p (that is loss of tumor suppressor genes on these locations), and epidermal growth factor receptor gene amplification, have been proposed as sequential abnormalities participating in glioblastoma tumorigenesis. 1336685 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE LOH on chromosome 10 and p53 mutation were found together only in patients with glioblastoma multiforme (22%), suggesting that these genetic changes may accumulate during astrocytoma progression. 1346255 1992
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
0.100 Biomarker disease BEFREE The specificity of the elevated transcription of TGF-alpha, TGF-beta, bFGF and flg in glioblastoma cell lines is further suggested by the fact that the transcription of the proto-oncogene c-erbB2, which is overproduced in breast tumor cell lines, was not elevated in glioblastoma cell lines. 1347915 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.100 AlteredExpression disease BEFREE The specificity of the elevated transcription of TGF-alpha, TGF-beta, bFGF and flg in glioblastoma cell lines is further suggested by the fact that the transcription of the proto-oncogene c-erbB2, which is overproduced in breast tumor cell lines, was not elevated in glioblastoma cell lines. 1347915 1992
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
0.070 AlteredExpression disease BEFREE The specificity of the elevated transcription of TGF-alpha, TGF-beta, bFGF and flg in glioblastoma cell lines is further suggested by the fact that the transcription of the proto-oncogene c-erbB2, which is overproduced in breast tumor cell lines, was not elevated in glioblastoma cell lines. 1347915 1992