Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 GeneticVariation disease BEFREE Expression of the c-met gene was also confirmed in a glioblastoma tissue. 8647632 1996
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 GeneticVariation disease BEFREE This translational correlative component to the MET-PET clinical trials can lead to a better understanding of the existing controversies and can enhance our knowledge for future randomization of GBM patients based on their tumor gene signatures to achieve better prognosis and treatment outcome. 29164057 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 GeneticVariation disease BEFREE GBM individuals with MET-pathway pairs showed significantly shorter survival times than those with only MET amplification. 24911613 2014
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 GeneticVariation disease BEFREE Although the extent of the amplified domain varied, the close vicinity of the MET gene was the only region consistently amplified in these glioblastomas. 9402967 1997
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma. 29238047 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET. 31349699 2019
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Previously, it was demonstrated that treatment with cabozantinib (MET/VEGFR2/RET inhibitor) prolonged survival of mice carrying orthotopic patient-derived xenografts (PDX) of the MET-addicted glioblastoma model E98, yet did not prevent development of recurrent and cabozantinib-resistant tumors. 28751462 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Our data provide new insights into the potential application of miR-144-3p in GBM therapy by targeting MET and then inhibiting the downstream signaling. 26250785 2015
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Silencing c-Met decreased anchorage-independent colony formation and increased the survival of mice bearing intracranial GBM xenografts. 23359207 2013
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Amplified met gene linked to double minutes in human glioblastoma. 8280494 1993
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE These results indicate the possible existence of multiple mechanisms of MET activation in glioblastomas and that the activation system of proHGF/SF is important in progression of glioblastomas that express endogenous proHGF/SF and require ligand-dependent MET activation. 16106403 2006
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Tumour exosomes from cells harbouring PTPRZ1-MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma. 28504721 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE An HGF paracrine environment may enhance glioblastoma growth in vivo but did not indicate sensitivity to MET inhibition. 22203985 2012
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Our studies reveal a novel mechanism to alter the recycling process of MET in glioblastoma cancer cells by promoting the receptor degradation through a proteasome-sensitive and lysosome-dependent pathway through the ligand-independent activation of MET using anti-MET antibodies. 30760737 2019
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma. 31694905 2020
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE We show that the RTKs MET, EGFR, and PDGFR regulate microRNA-134 (miR-134) in GBM. 24440911 2014
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease LHGDN Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy. 19190120 2009
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Finally, combined treatment with BH3-mimetics and c-MET inhibitors results in significantly smaller tumors than each treatment alone in a PDX model system of glioblastoma. 29743557 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. 27748748 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE H1/pHGFK1 exerts anti-tumoural and radiosensitive activities mainly through the inhibition and reversal of IR-induced MET and ATM-Chk2 axis activities in glioblastoma. 29348487 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Furthermore, we showed that PKCδ was aberrantly activated in GBM cells by c-MET, a receptor tyrosine kinase hyperactivated in GBM. 26700818 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM. 28258444 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE We also showed that Wnt/β-catenin signaling activities in GBM are directly modulated by the addition of ligand-mediated MET activation or MET inhibition. 23258844 2013
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE Here, we review findings that associate MET expression and activity with a specific, genetically defined glioblastoma stem cell subtype, and data showing how MET sustains the stem cell phenotype in glioblastoma and other tumors. 23695554 2013
Entrez Id: 4233
Gene Symbol: MET
MET
0.400 Biomarker disease BEFREE In both cohorts, MET amplification was never detected in GBM devoid of strongly immunopositive cells. 26946354 2017