Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs frequently in glioblastoma (GBM) and contributes to chemo/radio-resistance in various cancers, especially in GBM. 31508283 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Importantly, MYST1 expression was lowly expressed in mesenchymal subtype of GBM and was positively correlated with EGFR expression in a cohort from The Cancer Genome Atlas. 31691527 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Four genes that were commonly altered in both primary and recurrent GBM were more prevalent in our cohort than reported in COSMIC: CDKN2A (86% vs. 53%) and CDKN2B (86% vs. 54%) deletions, EGFR activating mutation (52% vs. 10%) or amplification (81% vs. 45%), and TERT mutation (95% vs. 51%). 30535594 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE For glioblastoma (GBM), the epidermal growth factor receptor (EGFR) gene is the most frequently mutated oncogenic driver and has therefore been considered an attractive target for therapy. 31054489 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The IC<sub>50</sub> values ranged from 17.34 µg/mL (towards U87MG.ΔEGFR glioblastoma cells) to 40.68 µg/mL (against CCRF-CEM leukemia cells) for FTB, from 16.78 µg/mL (towards U87. 30703492 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Here, we evaluated the efficacy of pan-EGFR inhibitor afatinib and Temozolomide (TMZ) combination on GBM in vitro and in vivo. 31215502 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE However, neither PTEN nor EGFR mutation, which is frequently present in glioblastoma, was detected. 30496796 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE According to the prevailing model, NHE9 overexpression leads to an increase in plasma membrane density of epidermal growth factor receptors (EGFRs) which consequently enhances GBM cell proliferation and migration. 31532058 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE As therapeutic decisions are increasingly guided by biomarkers, and EGFR abnormalities are common in GBM, thus representing a potential therapeutic target, we systematically evaluated methods of assessing <i>EGFR</i> amplification by multiple assays. 30796037 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The prognosis value of the risk signature was superior than known clinicopathological features in 1p/19q non-codel gliomas and was also highly associated with the following features: loss of CDKN2A/B copy number in mutant-IDH-astrocytoma; telomerase reverse transcriptase (TERT) promoter mutation, combined chromosome 7 gain/chromosome 10 loss and epidermal growth factor receptor amplification in wild-type-IDH-astrocytoma; classical and mesenchymal subtypes in glioblastoma. 31157866 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Glioblastomas (GBs) frequently display activation of the epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR). mTOR exists as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). 31510109 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. 31142380 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE We show that certain genes, like survivin and EGFR, are important for GBM survival, while NKCC1, is more crucial for cancer cell migration. 31026613 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE In addition, we found that specific FOXO3a activation recapitulated the molecular effects of EGFR inhibition, and that the FOXO3a activator trifluoperazine, a FDA-approved antipsychotic agent, reduced GBM cell growth. 30980364 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE Signal transduction via EGFR plays an essential role in glioblastoma. 31617054 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE We have previously shown that differential expression of the epidermal growth factor receptor in glioblastoma cells affects PpIX fluorescence. 31734545 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE All the EGFR-amplified or EGFRvIII mutant cases were IDH-wildtype glioblastomas and tested positive with IHC. 29912767 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE The IC<sub>50</sub> values of the compounds against carcinoma cells varied from 16.90 µM (in resistant U87MG.ΔEGFR glioblastoma cells) to 48.67 µM (against HepG2 hepatocarcinoma cells) for 1, from 7.85 µM (in U87MG.ΔEGFR cells) to 14.44 µM (in resistant MDA-MB231/BCRP breast adenocarcinoma cells) for 2, from 4.96 µM (towards U87MG.ΔEGFRcells) to 7.76 µM (against MDA-MB231/BCRP cells) for 4, and from 0.07 µM (against MDA-MB231 cells) to 2.15 µM (against HepG2 cells) for doxorubicin. 30836216 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE EGFR-amplified diffuse gliomas are "glioblastoma-like" in their behavior and may represent undersampled glioblastomas, or subsets of IDH-wildtype diffuse gliomas with inherently aggressive biology. 30496526 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE These data provide early evidence that combining HDAC and EGFR inhibition may be an effective strategy to reduce GBM growth, through a mechanism possibly involving STAT3. 30887411 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE High levels of NO66 in glioma and glioblastoma tissues predict poor patient prognosis, and NO66 is required for EGFR expression and glioblastoma cell proliferation. 31704826 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 GeneticVariation disease BEFREE Abnormal activation of epidermal growth factor receptors (EGFRs) due to amplification, mutation, or both of the <i>EGFR</i> gene is common in glioblastomas. 31284441 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE However, EGFR amplification is poorly represented in glioblastoma cell lines. 30509096 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 AlteredExpression disease BEFREE Neutralizing antibody against BTC abrogated activation of both EGFR and NF-ᴋB in response to inhibition of STAT3; with combinatorial blockade of STAT3 and BTC inducing apoptosis in glioblastoma cells. 31678994 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 Biomarker disease BEFREE We also identify a role of extracellular HA (via CD44) in altering the effect of erlotinib in GBM EGFR + cells by modifying STAT3 phosphorylation status. 31352310 2019