Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | Biomarker | disease | BEFREE | PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. | 26874904 | 2016 | ||||
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0.070 | Biomarker | disease | BEFREE | Starting from the observation that the growth-inhibitory and proapoptotic effects of miR-340 correlate with the accumulation of p27 in lung adenocarcinoma and glioblastoma cells, we have analyzed the functional relationship between miR-340 and p27 expression. miR-340 targets three key negative regulators of p27. | 25151966 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | The compound-induced p27 reduction was also seen in three additional glioblastoma lines, T98G, U251 and U118 as well as in mouse embryonic fibroblasts. | 17312389 | 2007 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The naturally occurring mutated form of the epidermal growth factor receptor, deltaEGFR (also named EGFRvIII and de2-7EGFR), greatly enhances glioblastoma (GBM) cell growth in vivo through several activities, such as down-regulating p27 and up-regulating BclX(L) while increasing signaling through the RAS-MAPK and PI3-K cascades. | 15700833 | 2004 | ||||
|
0.070 | Biomarker | disease | BEFREE | Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. | 11909963 | 2002 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. | 12438278 | 2002 | ||||
|
0.070 | Biomarker | disease | BEFREE | In astrocytic gliomas, p27 decreases with anaplasia and is almost absent in glioblastomas. p27/kip1 was immunohistochemically studied in 37 oligodendrogliomas, categorized according to WHO classification. | 10603039 | 1999 |