Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma. 29557060 2018
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE SFV4miRT is an excellent candidate for treatment of glioblastoma multiforme and neuroblastoma with low IFN-β secretion.<i></i>. 27637889 2017
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Previously, we have shown that intracranial interferon-beta (IFN-β) gene therapy by locally administered adeno-associated viral vectors (AAV) successfully treats noninvasive orthotopic glioblastoma models. 28098415 2017
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 GeneticVariation disease BEFREE B18R expression by SFV4 increased its oncolytic capacity in vitro against murine glioblastoma (CT-2A), regardless of the presence of exogenous IFN-β. 29159280 2017
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE We also created a highly secretable variant of immune cytokine IFNβ to enhance its release from engineered mouse mesenchymal stem cells (MSC-IFNβ) and assessed whether surgical resection of intracranial GBM tumor significantly enhanced the antitumor efficacy of targeted on-site delivery of encapsulated MSC-IFNβ.<b>Results:</b> We show that tumor debulking results in substantial reduction of myeloid-derived suppressor cells (MDSC) and simultaneous recruitment of CD4/CD8 T cells. 28912136 2017
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma. 27194146 2016
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE It was demonstrated that early IFN-β induction regulated virus replication in glioblastoma tbl98G cells, whereas delayed IFN-β induction resulted in efficient virus replication in neuroblastoma SK-N-SH cells. 25920530 2015
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells. 26441059 2015
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Our data thus suggest that IFN-β could be an effective agent not only through its cell growth inhibitory effect on GSCs but also as a means of targeting the interconversion between GSCs and non-GSCs, indicating the possibility of IFN-β being used to prevent treatment resistance and recurrence in glioblastomas, via the inhibition of undifferentiated features. 26397698 2015
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells. 24526161 2014
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE These results indicate that the PAMAM-R/pORF-IFN-β polyplex is an effective therapeutic candidate for glioblastoma multiforme due to its selective induction of apoptosis in tumor cells. 23384727 2013
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE The Japan Clinical Oncology Group (JCOG) brain tumor study group has recently began a randomized phase II study to evaluate the clinical effectiveness of combination therapy with TMZ and IFN-β in glioblastomas. 21805051 2011
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE A similar synergy was seen in a rat orthotopic brain GM model with 9L-L/R in vivo; therefore, these results suggest that BioKnife-IFNβ may have significant potential to improve the survival of GM patients in a clinical setting. 20606645 2010
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE In this study we investigated the effect of intracerebroventricular (ICV) injection of an adeno-associated virus (AAV) vector encoding human interferon-beta (AAV-hIFN-beta) on glioblastoma growth. 19197327 2009
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE We analyzed the MGMT promoter methylation and TP53 mutations in 45 malignant astrocytomas (16 anaplastic astrocytomas and 29 glioblastomas multiforme) treated prospectively with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, interferon-beta and radiation therapy, and evaluated their clinical usefulness. 15455376 2005
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 GeneticVariation disease BEFREE We performed a pilot clinical trial of safety and effectiveness of this interferon beta gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). 14965379 2004
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Our results reveal the following: (a) for those cases in which loss has occurred, the region of common loss lies on the short (p) arm of the chromosome; (b) loss of genetic information from the short arm of chromosome 9 occurs frequently in glial tumors of intermediate (anaplastic, grade III) and high (glioblastoma, grade IV) histological malignancy (10 of 20 cases) but not in tumors of low (grade II) histological malignancy (0 of 10 cases); (c) tumors with 9p deletions are hemi- or nullizygous for interferon beta-1 and the interferon alpha gene cluster; (d) cases of interferon nullizygosity occur exclusively among tumors of highest histological malignancy (glioblastoma). 1998958 1991
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 AlteredExpression disease BEFREE The results of the present study indicate that multidrug-resistant human glioblastoma multiforme cells retain their increased sensitivity to the antiproliferative activity of the combination of IFN-beta plus IFN-gamma, and differences in antigenic phenotype are apparent in independent multidrug-resistant glioblastoma multiforme clones. 1653364 1991