Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | The ability of IL‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for GBM was researched in the GBM tumor model. | 29328445 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | HSV-TK/IL-2 gene therapy for glioblastoma multiforme. | 19565921 | 2009 | ||||
|
0.380 | Biomarker | disease | BEFREE | Reverse transcription-polymerase chain reaction (RT-PCR) analysis for interleukin 4 receptor alpha (IL-4Ralpha), interleukin 13 receptor alpha1 (IL-13Ralpha1), interleukin 2 receptor gammac (IL-2Rgammac) were performed on total RNA extracted from 10 non-invasive pituitary adenomas, 30 invasive pituitary adenomas, one glioblastoma multiforme, one normal human pituitary tissue sample and one normal human brain tissue sample. | 17398005 | 2007 | ||||
|
0.380 | Biomarker | disease | BEFREE | Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results. | 15891772 | 2005 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Glioblastoma cell lines transduced with this vector could produce high levels of IL-2 for up to 2 weeks, long enough to elicit an antitumor immune response. | 10066092 | 1998 | ||||
|
0.380 | Biomarker | disease | BEFREE | Four patients affected by glioblastoma recurrence were treated with a gene therapy-immunotherapy protocol consisting of intratumoral injections of culture cells producing a retroviral vector which expresses human interleukin-2 and the herpes simplex virus thymidine kinase genes. | 9711724 | 1997 | ||||
|
0.380 | Therapeutic | disease | CTD_human | These results support the evaluation of this form of IL-2 gene therapy in additional patients with glioblastoma. | 7719933 | 1995 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | These results support the evaluation of this form of IL-2 gene therapy in additional patients with glioblastoma. | 7719933 | 1995 | ||||
|
0.380 | Biomarker | disease | BEFREE | T cell suppressor factor produced by human glioblastoma cells inhibits T cell proliferation in vitro and more specifically interferes with interleukin-2 (IL-2)-dependent T cell growth. | 3497030 | 1987 |