Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. 31289362 2019
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Thus, our findings provide a rationale for targeting TGF-β1 or miR-10b for the treatment of GBM. 28393237 2017
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE We show that GBM is strictly "addicted" to miR-10b and that miR-10b gene ablation is lethal for glioma cell cultures and established intracranial tumors. miR-10b loss-of-function mutations lead to the death of glioma, but not other cancer cell lines. 28153089 2017
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 AlteredExpression disease BEFREE MicroRNA-21 (miR-21) and microRNA-10b (miR-10b) are oncomiRs overexpressed in glioblastoma, promoting many aspects of cancer biology. 27508339 2016
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells. 27467502 2016
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Comparative analysis of The Cancer Genome Atlas revealed a strong correlation between miR-10b and multiple E2F target genes in GBM and low-grade glioma. 25738367 2015
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Inhibition of miR-10b strongly reduced cell invasion and migration in glioblastoma cell and stem cell lines while overexpression of miR-10b induced cell migration and invasion. 23307328 2013
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. 23034333 2012
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Recent data indicate that microRNA-21 and microRNA-10b are significantly elevated in glioblastoma multiforme (GBM) suggesting their role in the regulation of multiple genes associated with cancer. 22766763 2012
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 AlteredExpression disease BEFREE The levels of miR-10b and miR-21 are found significantly increased in the CSF of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions. 22492962 2012
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE Nineteen and 26 microRNAs exhibited cohort-dependent (including hsa-miR-10b with therapy and hsa-miR-486 with race) and independent associations with glioblastoma, respectively. 21737610 2011
Entrez Id: 406903
Gene Symbol: MIR10B
MIR10B
0.100 Biomarker disease BEFREE In contrast, in glioblastoma (GBM), the most common and malignant primary brain tumor, miR-10b promotes proliferation and prevents death of cancer cells by targeting cell cycle inhibitors and pro-apoptotic genes. 21795860 2011