Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease UNIPROT
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GenomicAlterations disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 CausalMutation disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE We used a combination of Northern blot analysis, protein truncation assays, and sequence analysis to determine the types and frequency of PTEN mutations in glioma cell lines so that we could define appropriate recipients to assess the growth suppressive function of PTEN by gene transfer. 9356475 1997
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. 9090379 1997
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE A new tumor suppressor gene PTEN/MMAC1 was recently isolated at chromosome 10q23 and found to be inactivated by point mutation or homozygous deletion in glioma, prostate and breast cancer. 9671402 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Initial studies revealed mutations of PTEN in limited series of glioma cell lines and glioblastomas. 9619835 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The sequence analysis of PTEN/MMAC1 revealed nucleotide alterations in 1/8 (12.5%) low-grade gliomas in a tumor with LOH at l0q21-qtel and in 5/21 (24%) high-grade gliomas displaying LOH that always included 10q23-26. 9681833 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE A novel tumor suppressor gene, PTEN/MMAC1, has been recently shown to be mutated in gliomas, breast, prostate, kidney cancers and melanomas. 9692547 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Using the mutant PTEN glioma cell line, U87MG, as a transfection recipient for a series of PTEN alleles, we provide direct evidence that this capacity requires phosphatase activity. 9823298 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE The authors introduced wild-type PTEN complementary DNA into four human glioma cell lines (T98G, U-251MG, U-87MG, and A172) containing endogenous aberrant PTEN alleles. 10541240 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE In contrast, ectopic expression of wild type PTEN, but not the PTEN(G129R) mutant, in PTEN-mutant gliomas markedly sensitizes these cells to irradiation and to CD95-ligand (CD95L)-induced apoptosis. 10435616 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Six constitutional missense mutations of the p53 gene were identified (13.6%), but no mutations of the p16 and PTEN genes were found, suggesting that (1) germline p53 mutations contribute to a small portion of astrocytic tumors, (2) inherited mutations of the p16 and PTEN gene do not predispose to the development of gliomas, and (3) other genes are involved in glioma predisposition. 10589545 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. 10092130 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Rsa I digestion may help to identify this putative PTEN pseudogene which, according to RT-PCR analysis on glioma, fibroblast, brain and lung cells, does not appear to be transcribed. 10378766 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE The PTEN gene, located on 10q23.3, has recently been described as a candidate tumour suppressor gene that may be important in the development of advanced cancers, including gliomas. 10188904 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE To characterize the potential cellular functions of MMAC1, we expressed wild-type and several mutant variants of MMAC1 in the human glioma cell line, U373, that lacks endogenous expression. 10022807 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The tumour suppressor gene PTEN/MMAC1, which is mutated or homozygously deleted in glioma, breast and prostate cancer, is mapped to a region of 10q which shows loss of heterozygosity (LOH) in bladder cancer. 10360673 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Because PTEN negatively regulates on the downstream effects of phosphatidylinositol-3-kinase (PI3-K), we hypothesized that the loss of PTEN/MMAC1 and the activation of RAS may be largely equivalent because RAS is a known positive upstream regulator of PI3-K. We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis. 10766161 2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE These results suggest that mutation of the PTEN gene is a later event than that of the p53 gene in glioma progression and is associated with both the genetic pathways. 11051241 2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Using the C6 glioma cell line, which does not express measurable amounts of PTEN protein and in which in vitro invasiveness is MMP dependent, the authors determined that in vitro glioma cell invasiveness was significantly reduced when cells were preincubated overnight with LY294002 or wortmannin, two specific inhibitors of PI 3-K signaling. 11565871 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE These findings indicate that PTEN gene mutation contributes not only to the neoplastic evolution in gliomas but also to the meningeal dissemination of glioma cells. 11678426 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Our results showed that reintroduction of the MMAC/PTEN gene into human glioma U251 and U87 cells modified their phenotype and growth characteristics. 11709701 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE We investigated the mechanism of the PTEN-induced growth arrest in glioma cell lines. 11280773 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The tumour suppressor gene PTEN is also often somatically mutated in glioma, therefore it is attractive as a candidate gene for germline mutations in familial glioma. 11669337 2001