Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 AlteredExpression disease BEFREE Analysis of the RNA-Seq data from The Cancer Genome Atlas database showed that the increased SPP1 mRNA expression in lower-grade glioma was significantly associated with poor survival outcomes in patients with lower-grade glioma. 31295606 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE These infiltrating macrophages secrete SPP1, which sustains glioma cell survival and stimulates angiogenesis. 31185211 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE Both tumor-derived and host-derived OPN were critical for glioma development. 30307407 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE OPN expression increases in correlation to the glioma malignancy from 4.5 ± 1.8% (I) to 12.3 ± 1.2% of OPN+ cells (III). 30140373 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 AlteredExpression disease BEFREE We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine 123 efflux, sphere forming capacity and stemness marker expression. 28030801 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. 27563812 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE These strategies allow us to define an important role of OPN in conferring cancer hallmarks, which can be further applied to assess the functional roles of other candidate genes in glioma. 27198662 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 AlteredExpression disease BEFREE Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway. 25405848 2015
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 AlteredExpression disease BEFREE Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. 25658639 2015
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 GeneticVariation disease BEFREE Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort. 25277531 2014
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 AlteredExpression disease BEFREE Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. 23204518 2013
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE To elucidate the role of OPN in the process of glioma angiogenesis, endothelial progenitor cells (EPCs) were treated with conditioned media of human glioma SHG44 cells overexpressing OPN. 21616556 2011
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE Both OPN-a Mu and -c Mu promoted glioma cell invasion through alteration of the levels of uPA, MMP-2, and MMP-9 expressions and the activities of MMP-2 and MMP-9 via activation PI-3K/AKT/NF-kappaB signaling pathway. 20511184 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 GeneticVariation disease BEFREE We found significant evidence of an association between SPP1 promoter polymorphisms and glioma risk. 20505679 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease BEFREE This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. 19609945 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease RGD Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression. 16651633 2006
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 Biomarker disease CTD_human Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression. 16651633 2006
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.600 GeneticVariation disease BEFREE We also isolated and sequenced three types of splice variants in OPN from human glioma cell lines through polymerase chain reaction. 7837791 1995