Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Thus, our results demonstrate that activation of Wnt/β-catenin pathway involves an ATM/Chk2- independent PI3K/Akt/GSK-3 cascade in TMZ treated cells and further provides mechanistic basis for the chemoresistance of glioma to TMZ. 31758290 2019
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Regression analysis revealed a high correlation between ATM protein levels and SF2 for primary glioma cell strains, but not for established GBM cell lines. p53 status failed to predict radiosensitivity. 11380241 2001
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. 23620409 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE Therefore, we tested the hypothesis that polymorphisms and haplotypes in p53 and ATM could be associated with glioma and meningioma risk. 17151932 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Our study highlights the coordinated control of glioma cell proliferation and metabolism by ROS through (i) ATM-YAP1-driven apoptotic pathway and (ii) JNK-regulated metabolic adaptation. 24810048 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo. 28560406 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease BEFREE Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast. 12105990 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Coherent with in vitro findings, pharmacological inhibition of TERT by costunolide decreased lipid accumulation and elevated ATM expression in heterotypic xenograft glioma mouse model. 28833137 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma. 27108486 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease LHGDN ATM expression is therefore heterogeneous in the glioma cells examined. 16631604 2006
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma. 29378238 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE The relationship between ATM protein expression and radiosensitivity in 3 glioma cell lines was examined. 16631604 2006
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma. 25646660 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Reduction of ATM in a human glioma cell line lacking DNA-PKcs was accompanied by defective signaling through downstream substrates, post-irradiation. 15753361 2005
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GenomicAlterations disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 AlteredExpression disease BEFREE Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J. 20869334 2010
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker disease BEFREE Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein. 22257080 2012