Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 CausalMutation disease CGI
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE 1p19q LOH patterns and expression of p53 and Olig2 in gliomas: relation with histological types and prognosis. 20081802 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Glioma development is accelerated upon loss of the tumor suppressor p53. 20360385 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy. 20661249 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE A genomic analysis of the six genes identified in the glioma pathway by cBioPortal indicated that TMZ might exert biological effects via interaction with the tumor protein P53(TP53) signaling axis. 29152101 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease CTD_human A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. 21946351 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE A human glioma cell line (U-87MG) that expresses wild-type p53, one that expresses mutant p53 (T-98G), and a T-98G derivative (T-98G/p53) that was transfected with a wild-type p53 expression vector (pCDM8-p53/neo) were used. 10930016 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE A human glioma cell line (A172/mp53) stably transfected with a plasmid containing mutated p53 and a human cervical cancer cell line (HeLa/bcl-2) transfected with a bcl-2 expression plasmid were used. 18640498 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN A series of nine familial gliomas were characterized with 1-megabase resolution BAC array-based comparative genomic hybridization (aCGH) together with germline sequence analysis of TP53. 17656254 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE A significant correlation between the expression of mutant form of TP53 and the grade of the glioma was established. 20714943 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE A significant inverse correlation was observed between expression of miR-141-3p and p53 in glioma and normal brain tissues (R<sup>2</sup>=0.506, P<0.0001). 29050344 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE A specific TP53 low frequency variant has also been associated with glioma risk and validated in a separate data set. 24184969 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE A systematic screening for p53 mutations in surgical materials from patients with glioma revealed a 378C>G mutation that creates a stop codon at the position of amino acid residue 126. 28961258 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Absence of a functional p53 increases TMZ sensitivity in traditional glioma cell lines, an effect that is independent of MGMT status, and not seen in BTICs. 20593219 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma. 8285583 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE All but one of the tumours with TP53 mutation showed p53 immunopositivity, but 5 low-grade and 10 high-grade gliomas had p53 protein nuclear accumulation in the absence of detectable mutation. p53 status was unrelated to p21 expression. 11355303 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Also, the p14(ARF) expression in p53 wild-type gliomas was lower than levels in p53 mutated gliomas. 12447702 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Also, we found that linarin-reduced cellular proliferation of glioma was dependent on p53 up-regulation and Nuclear factor kappa-B (NF-κB)/p65-down-regulation, thereby inhibiting glioma cell growth. 28858735 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Although it remains imperfect, p53 expression with a threshold of 10% is a good surrogate marker for missense TP53 mutations and appears helpful in the setting of LGG phenotype diagnosis. 24590827 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Although mutation or inactivation of the p53 tumor suppressor gene occurs at early stages in gliomas and is associated with tumor progression, many tumors including high-grade glioblastoma multiforme carry a functionally intact p53 gene. 10100717 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. 8965097 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE As mutations of the p53 tumor suppressor gene represent an early event in the development of gliomas, we attempted to determine whether both components of gliosarcomas share identical alterations of the p53 gene. 7666053 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Association of p53 tumor suppressor gene with paraclinical and clinical modalities of gliomas patients in Malaysia. 15168228 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma. 23096687 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. 16818615 2006