Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. 31201181 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Also, in vivo tumor therapy experiments demonstrated that the longest survival period along with the greatest downregulation of EGFR expression in tumor tissues was observed in mice with an intracranial U87 glioma treated with T7-LPC/siEGFR NPs compared with mice receiving other formulations. 27374198 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Taken together, we conclude that DeltaEGFR is required for both glioma establishment and maintenance, and that gliomas undergo selective pressure in vivo to employ alternative compensatory pathways to maintain aggressiveness in the event of EGFR silencing. 20133782 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). 22886559 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Cetuximab insufficiently inhibits glioma cell growth due to persistent EGFR downstream signaling. 20504227 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. 8965097 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Epidermal growth factor receptor (EGFR) has been shown to be overexpressed in a variety of tumors and is one of the important mediators responsible for the development of high-grade gliomas, especially in primary glioblastomas. 19565911 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease LHGDN Aggressive human brain tumours (gliomas) often express a truncated and oncogenic form of the epidermal growth factor receptor, known as EGFRvIII. 18425114 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE In this minireview we describe the expression of GPCR, ADAMs and EGFR ligands in human glioma brain tumors and the characteristics of small molecule ADAMs inhibitors. 18991757 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE To establish a whole-animal approach that can be used to readily identify individual pathometabolic signaling factors, we induced glioma formation in the adult Drosophila brain by activating the EGFR-PI3K pathway. 30357574 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Furthermore, a negative correlation was detected between the protein expression of PER2 and PCNA and EGFR in glioma. 25688509 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. 24054399 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. 21960689 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The growth of established EGFR- or EGFRvIII-overexpressing glioma xenografts was suppressed by M27-28BBZ CAR T cells as well. 30201736 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE In our work, we explored the optimized preparation of [<sup>89</sup>Zr]Zr-DFO-nimotuzumab, and evaluated <sup>89</sup>Zr-labeled monoclonal antibody (mAb) construct for targeted imaging of epidermal growth factor receptor (EGFR) overexpressed in glioma. 30826708 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Subsequent cell recovery experiment indicated that microRNA-374b and EGFR had a mutual regulation and could affect the malignant progression of glioma all together. 31173297 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE EGFR overexpression correlates in experimental gliomas with increased angiogenesis, edema, and invasion. 16361543 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to the activity of the unfolded protein response (UPR) sensor IRE1α. 24330607 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE However, the relationship between EGFR genetic polymorphisms and glioma remains unclear in the Chinese population. 25514356 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE The purified antibody selectively bound the glioma deletion mutant as compared to the intact epidermal growth factor receptor as assessed by immunocytochemistry, immunofluorescence, immunoprecipitation with gel electrophoresis, and binding experiments using radioiodinated antibody. 1693434 1990
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Induction of differentiation and TERT-knockdown in glioma stem cells led to a marked reduction in EGFR expression, cancer stemness, and anticancer drug resistance. 21193962 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE LRIG1 functions as a tumor suppressor in the pathogenesis of glioma via EGFR/Akt/c-Myc activation. 23124613 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE However inhibition of EGFR did enhance the chemo- and radio-sensitivity of both canine and human glioma CSCs, enabling this resistant, tumourigenic population of cells to be effectively targeted by conventional therapies. 29069805 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma. 21245103 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease GWASCAT Chromosome 7p11.2 (EGFR) variation influences glioma risk. 21531791 2011