Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 CausalMutation disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GenomicAlterations disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE In this study we have determined the prevalence of amplification of the proto-oncogenes c-erb B1 (= epidermal growth factor receptor gene), c-erb B2 and c-myc in 44 human intracranial tumours (27 gliomas, six metastases to the brain and 11 meningiomas). 2908290 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE EGFR gene amplification was found in six of the eight glioma biopsies and their corresponding xenografts. 3258189 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE The purified antibody selectively bound the glioma deletion mutant as compared to the intact epidermal growth factor receptor as assessed by immunocytochemistry, immunofluorescence, immunoprecipitation with gel electrophoresis, and binding experiments using radioiodinated antibody. 1693434 1990
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE The RNase A protection assay showed minimal differences in the quantity of EGFR mRNA among the 13 glioma lines, while the D-245 MG and D-270 MG xenografts expressed approximately 10-20 times as much EGFR mRNA as the corresponding cell lines. 2253244 1990
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Malignant human glioma D-298 MG amplifies a rearranged epidermal growth factor receptor (EGFR) gene (c-erbB proto-oncogene), resulting in an in-frame deletion of 83 amino acids in domain IV of the extracellular domain of the EGFR. 1678600 1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The role of epidermal growth factor receptor (EGFr) in gliomas is presented. 2098494 1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE In vitro glioma cell lines coexpress EGFR and at least one of its ligands, transforming growth factor alpha, suggesting the existence of an autocrine growth stimulatory loop. 2009534 1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 PosttranslationalModification disease BEFREE Particularly salient are the following: (1) gene amplification is related to increasing grade of human glioma malignancy and occurs in approximately 40% of the most common and most malignant variety of glioma, glioblastoma multiforme (GBM), (2) by far the most commonly amplified gene in glioblastomas is the epidermal growth factor receptor (EGFR) gene, which is amplified in about one third of GBMs, (3) a small percentage of GBMs amplify N-myc or the novel sequence gli, (4) the EGFR gene is rearranged in at least half of gliomas in which it is amplified, and (5) EGFR gene rearrangement results in external domain deletions that yield truncated EGF receptors. 1374522 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. 1322795 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. 8052651 1994
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The finding of MET and EGFR independently amplified in glioma lends further support to a crucial role of chromosome 7 in the development of gliomas. 8017863 1994
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE We have previously identified in human glial tumors an 801-bp in-frame deletion within the epidermal growth factor receptor gene that created a novel epitope at the junction. 7585629 1995
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. 8965097 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Gene transfection-mediated overexpression of beta1,4-N-acetylglucosamine bisecting oligosaccharides in glioma cell line U373 MG inhibits epidermal growth factor receptor function. 9083062 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Identical aberrant EGFR mRNA was confirmed in these glioma and human glioma xenografts by Southern blotting. 9216693 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Furthermore, EGFR targeting significantly enhanced Ad gene delivery to 7 of 12 established glioma cell lines and to 6 of 8 cultured primary gliomas. 9865732 1998
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE These results suggest that aberrant EGFR affects the malignancy of glioma by stimulating proliferation and inhibiting apoptosis. 9879464 1998
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Data presented here indicate the existence of a 190 kDa mutant form of the EGFR in A-172 glioma cells that is substantially different from the deletion mutants characterized previously. 9692551 1998
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE A single-chain antibody fragment, MR1(scFv), with specific binding to epidermal growth factor receptor-vIII (EGFRvIII), was produced, radiolabeled, and evaluated for biodistribution in human glioma-bearing athymic mice. 10389943 1999
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE To address this issue, we examined the expression of EGFR using immunohistochemistry and screened for amplification of the EGFR gene using a competitive PCR in a series of 27 archival pediatric high-grade nonbrainstem gliomas treated consecutively at our institution between 1975 and 1992. 10430083 1999
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The growth of U87 MG xenografts, a glioma cell line that endogenously expresses approximately 10(5) EGFRs in the absence of gene amplification, was not inhibited by mAb 806. 11454674 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Glioblastoma multiforme (GBM) is the most aggressive type of glioma and GBMs frequently contain amplifications or mutations of the EGFR gene. 11514572 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Mutations in the epidermal growth factor receptor occur frequently in a number of human tumours including gliomas, non-small-cell lung carcinomas, ovarian carcinomas and prostate carcinomas. 11484948 2001