Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 Biomarker disease CTD_human We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASDB We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872). 20212223 2010
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933 2010
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058 2010
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). 21350045 2011
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Two recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in (or near) TERT (5p15), CCDC26 (8q24), CDKN2A/B (9p21), PHLDB1 (11q23), and RTEL1 (20q13) are associated with infiltrating glioma. 21356187 2011
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASDB Chromosome 7p11.2 (EGFR) variation influences glioma risk. 21531791 2011
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT Chromosome 7p11.2 (EGFR) variation influences glioma risk. 21531791 2011
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990 2011
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). 22886559 2012
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787 2013
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 Biomarker disease BEFREE Our data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1. 23300798 2012
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis. 24935770 2015
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1). 25713050 2015
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050 2015
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 Biomarker disease BEFREE Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility. 26610392 2015
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma risk in Chinese Han population. 28886307 2017
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. 29743610 2018
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease GWASCAT Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility. 30714141 2019
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Previous studies have revealed that PHLDB1 single-nucleotide polymorphisms (SNPs) are associated with glioma risk. 30868356 2019
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1
0.500 GeneticVariation disease BEFREE Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers. 31721021 2020