Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. 15531913 2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. 18202704 2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease LHGDN Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. 12118245 2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN Novel therapeutic approaches using TRAIL or agonistic TRAIL receptor antibodies in combination with proteasome inhibitors may represent a promising approach to reactivate apoptosis in therapy-resistant high-grade gliomas. 18341587 2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. 15774464 2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease LHGDN Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. 14534533 2003
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. 19229339 2009
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human The results of the present study show that the anti-diabetic drug troglitazone sensitizes human glioma and neuroblastoma cells to TRAIL-induced apoptosis. 16820965 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Weak expression of DR5 in primary glioma might limit the therapeutic application of Apo2L/TRAIL in human glioblastoma patients. 17595512 2007
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector. 14605667 2003
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Finally, MSCs expressing TRAIL improved the median survival of irradiated mice bearing intracranial U87 glioma xenografts in comparison with nonirradiated and irradiated control mice. 24002694 2014
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability. 30642878 2019
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Moreover, Ad-Apo2L/TRAIL gene transfer inhibits soluble His-tagged Apo2L/TRAIL-induced apoptosis, strongly suggesting that the adenovirally encoded full-length Apo2L/TRAIL is not a suitable molecule for glioma cancer gene therapy. 12587790 2003
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE These PEI-PLL-transfected mesenchymal stem cells with HSV-TK and TRAIL genes have the potential to treat glioma both in vitro and in vivo. 30223091 2018
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Human glioma organotypic slices treated with AdsTRAIL demonstrated apoptosis induction and caspase activation. 21368892 2011
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE The effect of NP-TRAIL was examined on the apoptosis of glioma cells and self-renewal of glioma stem cells (GSCs). 23144078 2013
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Since PKCε has been implicated in the resistance of glioma cells to TRAIL, we examined its role in TRAIL and proteasome inhibitor-induced apoptosis. 21440622 2011
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Inhibition of either PPARgamma or MEK1/2 blocked the Troglitazone-mediated phosphorylation of BAD and further increased the synergistic induction of glioma cell death by TRAIL and Troglitazone. 19158480 2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE It also sensitizes human glioma cells against TRAIL by increasing DR5 expression. 21392090 2011
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE We analyzed the expression of TRAIL and its receptors in a panel of human brain tumors (n = 34) and in four glioma cell lines in comparison to normal brain tissue. 10198234 1999
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE The authors first examined sensitivity to TRAIL and expression of TRAIL receptors in four established and four primary cultured glioma cell lines by using viability and fluorescent apoptosis assays. 15844877 2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE We thus established the TRAIL resistance models on glioma by using the U87 and U251 cell lines (U87/R and U251/R). 31056533 2019
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Digitoxin increases sensitivity of glioma stem cells to TRAIL-mediated apoptosis. 28511914 2017
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE We found that osthole and TRAIL alone, had no effect on apoptosis, but combined treatment with osthole and TRAIL markedly induced apoptosis in Caki (renal carcinoma), U251MG (glioma) and MDA-MB-231 (breast carcinoma) cells. 28350076 2017
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Taken together, these findings suggest that resistance to TRAIL by lack of TRAIL receptors on glioma is restored by genotoxic agents, which support the new strategies for tumour killing by TRAIL-bearing cytotoxic cells in combination with genotoxic treatment. 12610517 2003