Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE To determine whether the increased prostaglandin production is due to enhanced expression of PHS-2 and whether the up-regulation of PHS-2 has any correlation to histopathological findings in brain tumors, we evaluated the profile of PHS expression in several human glioma cell lines and surgical specimens from patients with various types of brain tumors. 11563634 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease LHGDN Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds. 15361550 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds. 15361550 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Exposure to COX-2-overexpressing glioma induced mature DCs to overexpress IL-10 and decreased IL-12p70 production. 15383564 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE We compared effects of interferon-gamma (IFNgamma) on cyclooxygenase-2 (COX-2) expression in malignant human glioma cell lines and cultured primary human astrocytes. 15465602 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease CTD_human The induction of cyclooxygenase-2 (COX-2) expression is associated with more aggressive gliomas and poor survival. 15561105 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE All COX-2 inhibitors reduced proliferation of the glioma cell lines irrespective of their COX-2 expression level. 17729162 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas. 17616668 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease LHGDN We found that EGF-mediated stimulation of EGFR tyrosine kinase in human glioma cell lines induces expression of both COX-2 mRNA and protein. 17616668 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines. 19029777 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease LHGDN The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines. 19029777 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE A CD133(+)-enriched U87 glioma cell population, isolated from parental U87 cells with magnetic cell sorting technology, also grew as neurospheres and showed enhanced COX-2 expression. 19272160 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. 19169273 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. 19925030 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively). 20406895 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE This led to our interest in assessing the response of glioma cell lines to treatment with celecoxib, a selective COX-2 inhibitor. 21220497 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE COX-2 regulates the proliferation of glioma stem like cells. 21763744 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Expression analysis further revealed that Cox-2 was elevated in glioma and associated with survival of patients. 22406049 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Increased COX-2 expression directly correlates with glioma grade and is associated with shorter survival in glioblastoma (GBM) patients. 24659686 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Further, targeting MET and Cox-2 may represent an attractive target therapy for glioma. 26097553 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. 25966079 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Therefore, COX-2 and survivin may be sensitive predictors of a negative clinical prognosis for patients with glioma. 28789345 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Paraffin-embedded glioma specimens were detected for the COX-2 expression using immunohistochemistry. 28306608 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Activation of PTGS2/NF-κB signaling pathway enhances radiation resistance of glioma. 30740906 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma. 31438982 2019