Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 CausalMutation disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The purpose of this study was to clarify the incidence of B-RAF mutations and their possible relation with tumor progression in a series of 82 human gliomas, including 49 astrocytic and 33 oligodendroglial tumors. 15791479 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 AlteredExpression disease BEFREE We now report that AAL881, a novel low-molecular weight inhibitor of the kinase activities associated with B-RAF, C-RAF (RAF-1), and VEGF receptor-2 (VEGFR2), showed activity against glioma cell lines and xenografts. 16951188 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Using the BRAF(V600E)-specific inhibitor PLX4720, pharmacologic blockade of BRAF revealed preferential antiproliferative activity against BRAF(V600E) mutant cells in vitro, in contrast to the use of shRNA-mediated knockdown of BRAF, which inhibited cell growth of glioma cell lines regardless of BRAF mutation status. 22038996 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Tandem duplications involving the BRAF kinase gene have recently been identified as the most frequent genetic alteration in sporadic pediatric glioma, creating a novel fusion protein (f-BRAF) with increased BRAF activity. 23152448 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE BRAF mutation is seen in melanoma, papillary thyroid carcinoma (including papillary thyroid carcinoma arising from ovarian teratoma), ovarian serous tumours, colorectal carcinoma, gliomas, hepatobiliary carcinomas and hairy cell leukaemia. 23594689 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Additionally, we show that activating BRAF mutations play a central role in both low and high grade glial tumors. 23592488 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease CTD_human Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. 23583981 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE BRAF alterations in pediatric low grade gliomas and mixed neuronal-glial tumors. 23612919 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE In this report, we highlight advances in Nf1-GEM modeling and review new experimental evidence that supports the emerging concept that Nf1- and KIAA1549:BRAF-induced gliomas arise from specific cell types in particular brain locations. 23624918 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE However, a previous study on BRAF V600E mutation in paediatric glioma revealed a BRAF mutation in one of two tested DIAs/DIGs. 23822828 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The growth inhibitory effects of UAI-201 correlated with the BRAF-V600E genotype of the glioma cell lines. 24721513 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE We report a new IDH1 mutation associated with BRAF mutation in a very unusual glial tumor. 24857351 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Our data support clinical evaluation of BRAF(V600E) and EGFR targeted therapy in treating BRAF(V600E) glioma. 26023796 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE One of our E-GBM patients with initial gross total resection quickly recurred within 4 months, required a second resection, and then was placed on vemurafenib; she remains tumor free 21 months after second resection without neuroimaging evidence of residual disease, adding to the growing number of reports of successful treatment of BRAF-mutated glial tumors with drug. 25581727 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Our data indicate that BRAF(V600E) is a common genetic alteration in low-grade glial tumors with neuronal component or differentiation. 25346165 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE Development of selective inhibitors of BRAF has improved the survival of patients with melanoma and offers potential new therapeutic strategy in children with BRAF-mutant glioma. 27494648 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE For colorectal carcinoma, thyroid cancer, malignant melanoma and gliomas BRAF V600E immunostaining is sufficient for screening purposes. 27350555 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE We discuss differential diagnosis of the tumor, and review previously described diffuse gliomas with the BRAF V600E mutation. 26445861 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. 26384810 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE CDKN2A, and PTEN in high-grade gliomas, followed by BRAF fusions in low-grade gliomas and H3F3A mutations in pediatric gliomas. 26681766 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE The researchers have started a second trial for patients with glioma and other BRAF-mutant tumor types, this time evaluating dabrafenib combined with trametinib. 28062673 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas. 28727518 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. 27611946 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE However, it is unclear whether gliomas harboring BRAF mutations can be invariably regarded as these glioma subtypes or their derivatives. 27792249 2017