Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Homodisomy of chromosome 17p (CNLOH 17p) is a frequent feature in IDH-mutated 1p19q non-codeleted gliomas (group 2). 27401888 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 AlteredExpression disease BEFREE Several alterations like <i>IDH1/2</i> mutations that interfere with "epigenetic modifier" enzymes, the mutations of the histone 3 variants H3.1 and H3.3 that alter the global H3K27me3 levels and the altered expression of histone methyltransferases and demethylases are considered potentially druggable targets in glioma and molecules targeting these alterations are being tested in preclinical and clinical trials. 30386738 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Our study provides direct evidence that mutation of IDH1 profoundly inhibits the growth of glioma cells, and we speculate that this is the major factor behind its association with prolonged survival in glioma. 24362902 2014
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Mutations in the IDH1 gene at position R132 coding for the enzyme cytosolic isocitrate dehydrogenase are known in glioma and have recently been detected also in acute myeloid leukemia (AML). 20805365 2010
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE Among IDH-wildtype gliomas, an even higher portion (44.4%, 67/151) showed significantly larger BTVs in the early summation images, which was observed in 5.3% (5/94) of IDH-mutant gliomas only: most of the latter had significantly smaller BTVs in the early summation images, i.e. 29487977 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Examination of the relationship between the mutation status and other pertinent variables demonstrated a significant male predominance among IDH1-mutated gliomas, most notably in grade III to IV astrocytic neoplasms. 23111198 2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE IDH mutations are a favorable prognostic factor for human glioma and can be used as biomarker for differential diagnosis and subclassification rather than predictor of response to treatment. 22002076 2011
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Our results indicate that to better treat gliomas, IDH mutation status should be included when determining WHO2007 grade in glioma patients. 27120786 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE We determined the levels of D-2-hydroxyglutarate in glioma tissues with IDH1 mutations. 24529257 2014
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Analysis of Raman spectra revealed increased intensities in spectral bands related to DNA in IDH1 mutant glioma while bands assigned to molecular vibrations of lipids were significantly decreased. 29761368 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. 19359588 2009
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE IDH2 mutations were associated with better outcomes compared with IDH wild-type gliomas (P < 0.05). 31833906 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE The metabolomics data were tested for correlation with glioma grade (high vs low), glioblastoma (GBM) versus malignant gliomas, and IDH mutation status. 26967252 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE To address this, we investigated molecular and prognostic features of grade III glioma with and without IDH1/2 mutation. 21971842 2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Interestingly, glutamate levels were significantly decreased in IDH1 mutant gliomas. 27154922 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE We investigated the impact of IDH1 mutations on spontaneous glioma growth rate, known to be an early prognostic factor.The mean tumor diameter was assessed on the first MRI performed at diagnosis and on a second MRI, performed immediately before surgery, in a series of 64 WHO grade II gliomas. 22392125 2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE The Student's t test and Mann-Whitney U test were used to evaluate differences in parameters of DWI and 3D pCASL between low and high grade as well as between mutant and wild-type IDH1 diffuse gliomas; receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance. 29777252 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE In the other high-recurrence groups, the median progression-free survival (PFS) and overall survival (OS) of patients with IDH mutant gliomas with TP53 mutations were significantly longer than those of patients with IDH wild-type gliomas. 26558387 2015
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE IDH1 mutated paralimbic glioma shared many parameters with the purely insular glioma in respect to growth patterns, survival, and microRNA profile, but differed significantly from the IDH1 wild type paralimbic gliomas. 26586262 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE rLTL was measured by qPCR in a Swedish population-based glioma case-control cohort (421 cases and 671 controls). rLTL was related to glioma risk and health parameters associated with asthma and allergy, as well as molecular events in glioma including IDH1 mutation, 1p/19q co-deletion, and EGFR amplification. 30560391 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE After stratifying by histological and tumor genetic subtype, the most significant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or IDH2 (odds ratio (OR)=5.1, P=1.1×10(-31) and OR=4.8, P=6.6×10(-22), respectively). 22922872 2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE Intermediate survival was seen in patients with IDH1/2 mutant, but 1p/19q intact, mostly astrocytic gliomas, and in patients with IDH1/2 wild-type gliomas lacking the +7q/-10q genotype and TERT promoter mutation. 25783747 2015
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE We recently established that miRNAs are components of the IDH1 mutant-associated glioma CpG island methylator phenotype (G-CIMP) and specifically identified MIR148A as a tumor-suppressive miRNA within G-CIMP. 29545476 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 Biomarker disease BEFREE Mutations in the metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and chondrosarcoma patients. 23954893 2013
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.700 GeneticVariation disease BEFREE Sessions consisted of a total of 10 talks by international leaders in low-grade glioma research, mutant IDH1 biology and its application in glioma research, and treatment. 23373454 2013