Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers. 31721021 2020
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility. 30714141 2019
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. 30462709 2018
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. 29743610 2018
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 Biomarker disease BEFREE The present study focuses on the impact of MPHOSPH6, TNIP1 and several other genes (ACYP2, NAF1, TERC, TERT, OBFC1, ZNF208 and RTEL1) on telomere length and how this affects the prognosis of glioma. 28985021 2017
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 Biomarker disease BEFREE Thirteen well known genetic risk variants in TERT, EGFR, CCDC26, CDKN2A, CDKN2B, PHLDB1, TP53, and RTEL1 were selected for investigation of possible correlations with the glioma somatic markers: EGFR amplification, 1p/19q codeletion and protein expression of p53, Ki-67, and mutated IDH1. 26839018 2016
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE The pooled results indicated that the RTEL1 rs2297440 polymorphism moderately increased the risk of glioma in all genetic models. 26939676 2016
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050 2015
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1). 25713050 2015
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Subgroup analyses by ethnicity showed that RTEL1 rs6010620 polymorphism resulted in a higher risk of glioma among both Asians and Caucasians. 24523019 2014
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. 25227808 2014
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 24908248 2014
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASDB Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 24908248 2014
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE The A allele of rs6010620 in RTEL1 decreased the risk of developing glioma in the 12 case-control studies for all genetic models: the allele model (OR=0.752, 95%CI: 0.715-0.792), the dominant model (OR=0.729, 95%CI: 0.685-0.776), the recessive model (OR=0.647, 95%CI: 0.569-0.734), the homozygote comparison (OR=0.528, 95%CI: 0.456-0.612), and the heterozygote comparison (OR=0.761, 95%CI: 0.713-0.812). 25556444 2014
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE And it might be used to evaluate the glioma development risks to screen the above RTEL1 tagging SNPs and haplotypes. 23683922 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk. 24231251 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours. 23115063 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function. 23733245 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 Biomarker disease BEFREE Eight SNPs in/near seven different genes (TERT, EGFR, CCDC26, CDKN2A, PHLDB1, RTEL1, TP53) were significantly associated with glioma risk in the combined dataset (P < 0.05), with all associations in the same direction as in previous reports. 23280628 2013
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASCAT Genome-wide association study of glioma and meta-analysis. 22886559 2012
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease GWASDB Genome-wide association study of glioma and meta-analysis. 22886559 2012
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Among 99 SNPs, five independent susceptibility loci (20-62315594 in RTEL1, 20-62335293 in adenosine diphosphate ribosylation factor-related protein 1, rs3761121 in ZGPAT, rs1058319 in SLC2A4RG and rs5019252 in ZBTB46) were identified for glioma. 22387365 2012
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.500 GeneticVariation disease BEFREE Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population. 21920947 2011