Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease LHGDN Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells. 15201989 2004
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Here, we evaluated a combined PTEN and antisense hTERT gene therapy for experimental glioma in vitro and in vivo. 17310280 2007
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease LHGDN Association of telomerase gene hTERT polymorphism and malignant gliomas. 17410334 2007
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE However, HIF-1alpha stimulated whereas HIF-2alpha inhibited the hTERT promoter activity in these glioma cell lines. 17699105 2007
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease CTD_human Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. 18021753 2008
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 PosttranslationalModification disease LHGDN Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. 18021753 2008
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease CTD_human We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872). 20212223 2010
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933 2010
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058 2010
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Induction of differentiation and TERT-knockdown in glioma stem cells led to a marked reduction in EGFR expression, cancer stemness, and anticancer drug resistance. 21193962 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Glioma and human telomerase catalytic subunit-immortalized fibroblast BJ-5ta cell lines transduced with retrovirus vectors were assayed for killing activity by ganciclovir. 21347689 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). 21350045 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Two recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in (or near) TERT (5p15), CCDC26 (8q24), CDKN2A/B (9p21), PHLDB1 (11q23), and RTEL1 (20q13) are associated with infiltrating glioma. 21356187 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE The human telomerase reverse transcriptase (hTERT) promoter, an excellent tumor-specific promoter, has potential value for targeted gene therapy of glioma. 21801606 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Significant association with glioma risk was observed for rs2853677 [GG vs. GA: adjusted OR = 1.46, p = 5.51 × 10(-6), GG vs. AA: adjusted OR = 1.72, p = 7.64 × 10(-6), GG vs. GA and AA: adjusted OR = 1.96, p = 6.8 × 10(-6)] in TERT and an uncommon CLPTM1L haplotype G-T-A of rs4635969, rs6554759 and rs414965 (haplotype frequency = 0.07) was associated with higher glioma risk compared with the most common G-C-G haplotype (adjusted OR = 1.44, simulated p = 6.00 × 10(-3) under additive model). 22213090 2012
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Recently, single nucleotide polymorphisms in the region of the human telomerase reverse transcriptase (hTERT) gene were associated with various malignancies, including glioma, lung and urinary bladder cancer, and telomerase RNA gene hTERC genotypes were recently linked to TL. 22539396 2012
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE We identified two tSNPs to be associated with glioma susceptibility (rs1695, GSTP1, P = 0.019; rs2853676, TERT, P = 0.039), which we confirmed using dominant and additive model analyses. 22795327 2012
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1). 23115063 2013
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk. 24231251 2013
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics. 24722048 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Taken together, these data suggested that TERT rs2736100 polymorphism may contribute to glioma susceptibility. 24888789 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. 24908248 2014