Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Therefore, our results suggest that miR-93 might play an important role in glioma progression and uncover a novel mechanism for constitutive PI3K/Akt activation in gliomas. 25823655 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE The potential role of MAGI3 expression in PI3K/Akt signaling activation was further investigated by examining the correlation between MAGI3 expression and the expression of PI3K/Akt signaling downstream target genes in a glioma dataset using gene set enrichment analysis (GSEA). 26248734 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway. 31776938 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Genetic analyses demonstrated that EGFR and PI3K initiate malignant neoplastic transformation via a combinatorial genetic network composed primarily of other pathways commonly mutated or activated in human glioma, including the Tor, Myc, G1 Cyclins-Cdks, and Rb-E2F pathways. 19214224 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Therefore, LINC00526/EZH2/AXL/PI3K/Akt/NF-κB form a feedback loop in glioma. 31240814 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Taken together, our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis and that disruption of downstream CREB signaling attenuates tumor expansion. 29718345 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Our findings demonstrate that treatment with an ADP can suppress glioma cell migration and invasion via the PI3K/Akt/MMP-9 signaling pathway and provide a new platform for the development of drugs for treating glioma. 27686608 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway. 30784920 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Taken together, our findings shed new light on the miR-223/PAX6 pathway in glioma and this pathway might modulate the sensitivity of glioma to TMZ via regulating PI3K/Akt signaling pathway.. 28332226 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells. 29552118 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA. 30542720 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway. 29520611 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE The inhibitory effect of miR-219-5p on MAPK and PI3K pathways and glioma cell migration could be rescued by the overexpression of wild type EGFR and vIII mutant of EGFR (both lacking 3'-UTR and thus being insensitive to miR-219-5p) suggesting that the inhibitory effects of miR-219-5p were indeed because of its ability to target EGFR. 23690991 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE However, the role of different PI3K isoforms in glioma is still largely unclear. 22079609 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Moreover, the PI3K-mTOR inhibitor NVP-BEZ235, which is in clinical use, synergized with the lysosomotropic inhibitor of autophagy, chloroquine, another agent in clinical use, to induce apoptosis in glioma xenografts in vivo, providing a therapeutic approach potentially translatable to humans. 21062993 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting in preferential activation of PI3K/protein kinase B (Akt) pathway in glioma stem cell (GSC) relative to matched nonstem cell. 23569237 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE In the present study, KEGG PathwayFinder by gene correlation analysis was performed on the R2: Genomics Analysis and Visualization Platform, which revealed a high association between Ngb and the phosphatidylinositol 3‑kinase (PI3K)/AKT pathway using glioma data (GSE4290) from the Gene Expression Omnibus database. 29207186 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Sevoflurane downregulates insulin-like growth factor-1 to inhibit cell proliferation, invasion and trigger apoptosis in glioma through the PI3K/AKT signaling pathway. 31305291 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Taken together, our results suggest that LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression. 30372896 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE We demonstrate that the PTEN-PI3K axis regulates HIF1α in glioma models. 24162827 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE This RTK/PTEN/PI3K pathway leads to activated AKT and phospho-AKT levels are elevated in the majority of GBM tumor samples and cell lines, which studies show help glioma cells grow uncontrolled, evade apoptosis, and enhance tumor invasion. 21827416 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE DANCR promotes cisplatin resistance via activating AXL/PI3K/Akt/NF-κB signaling pathway in glioma. 29572052 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Similar to PI3K, NF-κB is associated with the regulation of BMSCs migration toward glioma. 26034878 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE These results suggest that Liq treatment enhances glioma cell susceptibility to TMZ by inhibiting the PI3K/AKT/mTOR pathway. 25351348 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Then we discovered that silencing EMP1 inhibited glioma cell invasion and proliferation through inhibiting the PI3K-AKT signaling pathway. 31111534 2019