Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 CausalMutation disease CGI
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE PI-3-K stimulation seems to be critical for CD95 receptor signalling since, first, inhibition of PI-3-K prevents CD95-mediated apoptosis and, second, CD95 receptor ligation fails to induce tyrosine phosphorylation or activation of PI-3-K in CD95-resistant glioma cells. 9446703 1998
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. 16170333 2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Here we show that expression of the gene encoding B7-H1 increases post transcriptionally in human glioma after loss of phosphatase and tensin homolog (PTEN) and activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. 17159987 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE These experiments show that a dual inhibitor of PI3Kalpha and mTOR augments the activity of EGFR blockade, offering a mechanistic rationale for targeting EGFR, PI3Kalpha, and mTOR in the treatment of EGFR-driven, PTEN-mutant glioma. 17804702 2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE The detailed study of these candidate genes and the molecular pathways regulating PI3K activation reveal that they are promising targets for the clinical management of patients with glioma. 18260157 2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Genetic analyses demonstrated that EGFR and PI3K initiate malignant neoplastic transformation via a combinatorial genetic network composed primarily of other pathways commonly mutated or activated in human glioma, including the Tor, Myc, G1 Cyclins-Cdks, and Rb-E2F pathways. 19214224 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. 19265662 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation disease BEFREE PTEN, an important negative regulator of the PI3K-Akt pathway, is also commonly mutated in glioma, leading to constitutive activation of Akt. 19549905 2009
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Moreover, the PI3K-mTOR inhibitor NVP-BEZ235, which is in clinical use, synergized with the lysosomotropic inhibitor of autophagy, chloroquine, another agent in clinical use, to induce apoptosis in glioma xenografts in vivo, providing a therapeutic approach potentially translatable to humans. 21062993 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. 19705067 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE These results suggest that the PI3K/AKT signaling pathway regulates glioma cell proliferation, in part via repression of the Wnt/β-catenin pathway. 20888802 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE Akt2 expression and PI3K activity were examined in 48 different grades of human glioma specimens and six normal brain tissue samples by immunohistochemistry and Western blot analysis. 20116920 2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE This RTK/PTEN/PI3K pathway leads to activated AKT and phospho-AKT levels are elevated in the majority of GBM tumor samples and cell lines, which studies show help glioma cells grow uncontrolled, evade apoptosis, and enhance tumor invasion. 21827416 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Our results demonstrate that combined inhibition of MEK and PI3K/mTOR is a rational strategy for the treatment of high-grade gliomas and may be an effective adjuvant therapy for this disease. 21057530 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE However, the role of different PI3K isoforms in glioma is still largely unclear. 22079609 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Recently, we reported that tyrosine-protein phosphatase non-receptor type 11 (SHP-2) and phosphatidylinositol 3-kinase (PI3K) mediate platelet-derived growth factor receptor-α (PDGFRα)-promoted glioma tumor growth and invasion. 21996738 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Blocking the phosphoinoside 3-kinase (PI3K)/Akt pathway with LY294002 or si-Akt also suppressed the self-renewal of sphere-cultured glioma cells. 22249269 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE We tested the biologic effects of a selective PI3K inhibitor NVP-BKM120 in a set of glioma cell lines. 22065080 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE This study suggests ADAM17 contributes to glioma progression through activation of the EGFR-PI3K-AKT signal pathway. 21480393 2012
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE The inhibitory effect of miR-219-5p on MAPK and PI3K pathways and glioma cell migration could be rescued by the overexpression of wild type EGFR and vIII mutant of EGFR (both lacking 3'-UTR and thus being insensitive to miR-219-5p) suggesting that the inhibitory effects of miR-219-5p were indeed because of its ability to target EGFR. 23690991 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting in preferential activation of PI3K/protein kinase B (Akt) pathway in glioma stem cell (GSC) relative to matched nonstem cell. 23569237 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression disease BEFREE In Drosophila melanogaster, activation of RTK and PI3K pathways in glial progenitor cells creates malignant neoplastic glial tumors that display many features of human glioblastoma. 23459592 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE We demonstrate that the PTEN-PI3K axis regulates HIF1α in glioma models. 24162827 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker disease BEFREE Interestingly, proteins regulated by phosphoinositide 3-kinase (PI3K)/Akt signaling, are among the top downregulated genes in gliomas associated with high percentage of IDH1 and IDH2 mutations. 24771584 2014