Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE Our previous study has shown that inhibitor of differentiation 4 (ID4) dedifferentiates Ink4a/Arf(-/-) mouse astrocytes and human glioma cells to glioma stem-like cells (induced GSCs or iGSCs). 21531766 2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. 7478535 1995
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE In gliomas, there is a wide variety of somatic mutations, such as, for instance, in p53, the epidermal growth factor receptor (EGFR) and p16. 11669337 2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease LHGDN Frequent homozygous deletion of p16/CDKN2A gene in malignant gliomas of Iranian patients. 19086579 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 AlteredExpression disease BEFREE Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. 20569441 2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE The presence of p16 gene mutations only in glioblastomas suggests that they are late events in glioma development. 8552400 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE Thus, despite the association between the sporadic forms of high-grade glioma and abnormalities of p16(INK4A), p15(INK4B), or CDK4, we found no evidence that germ-line mutations in the coding region of these three genes predispose to inherited glial tumors. 9815774 1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. 12907595 2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE These results suggest that p16/CDKN2 inactivation is a significant factor in the genesis and progression of gliomas and that the restoration of the wild-type p16 protein could have clinical and therapeutic utility. 8552379 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 AlteredExpression disease BEFREE Structural alterations in the p16INK4 gene were examined in early passage human glioma cell lines and related to the expression of p16 transcripts and protein. 8649864 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 AlteredExpression disease BEFREE We expected that downregulation of uPAR and overexpression of p16 using a bicistronic vector might cause a additive and cooperative effect in the suppression of glioma invasion and growth. 11791179 2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE The rate of homozygous CDKN2A/p16 deletions in glioma cell lines and in primary tumors. 10536182 1999
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease CTD_human We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE The occurrence of p16/CDKN2 germline mutations in 12 Icelandic melanoma kindreds (kindreds with two or more cases of melanoma or melanoma, pancreas and/or glioma cases) was examined. 10651484 1998
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE Our findings provide no evidence that p16(INK4A)/p14(ARF) and p53 mutations contribute significantly to familial glioma. 20455025 2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE These results suggest: (a) the involvement of P16INK4 in glioma progression; (b) that mechanisms other than mutation or deletion can down-regulate expression of the p16/CDKN2 gene; and (c) that the balance between CDK4 and its cognate inhibitor, P16INK4, may confer a cell growth advantage and facilitate tumor progression. 7728764 1995
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 AlteredExpression disease BEFREE The median methylation level of MGMT in glioma samples was 64.65% (IQR, 54.87%-74.37%) compared to 38.30% (IQR, 34.13%-45.45%) in healthy controls, and all revealed significant differences including P16. 29100349 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease BEFREE The Investigating and defining if glial tumors with CDKN2A/B and MTAP homozygous loss may be vulnerable to new forms of therapy, namely those affecting the methionine salvage pathway, was proven to be of importance. 30558563 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. 21754979 2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization. 7867008 1995
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 CausalMutation disease CGI
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma. 9053859 1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 GeneticVariation disease LHGDN P53 gene mutation and expression of MDM2, P53, P16 protein and their relationship in human glioma. 16696307 2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.600 Biomarker disease BEFREE Ink4a/Arf inactivation and epidermal growth factor receptor (EGFR) activation are signature lesions in high-grade gliomas. 12086863 2002