For example, 1,25-dihydroxyvitamin D<sub>3</sub> stimulates the expression of aromatase in human glioma but not in human neuroblastoma cells or rat astrocytes.
All glioma cell lines included here expressed CYP19A1 and letrozole exerted considerable cytotoxicity and decrease in aromatase activity against these cells (IC50, 0.1-3.5 μmol/L).
We assessed whether vitamin D, dexamethasone, and the glucocorticoid receptor antagonist mifepristone regulate the aromatase gene in human glioma, neuroblastoma, and breast cancer cells.