Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE The main aim of this study was to investigate whether interferon‑β (IFN‑β) (with its pleiotropic antitumor activities) could sensitize malignant glioma cells to TRAIL‑induced apoptosis using glioma cell lines. 31638255 2019
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma, and for fingolimod in acute ischaemic stroke and intracerebral haemorrhage. 31100209 2019
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Moreover, results provided evidence that delivery of IL-18 and IFN-β by BMSCs may be an excellent and promising approach to develop an effective treatment protocol for glioma therapy. 26252165 2015
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Interferon-β inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein 10. 25175315 2014
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 AlteredExpression disease BEFREE Lentivirus-based NOD2 knockdown in human foreskin fibroblasts (HFFs) and U373 glioma cells leads to enhanced HCMV replication along with decreased levels of interferon beta (IFN-β) and the pro-inflammatory cytokine, IL8. 24671169 2014
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Caspase activity and inhibition studies revealed the proapoptotic genes to mediate glioma cell sensitization to exogenous death ligands by IFN-β, but not to temozolomide or irradiation, indicating distinct pathways of death sensitization mediated by IFN-β. 24526161 2014
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Liposomes containing the human IFN-β gene were injected into the SHG44 glioma of nude mice to observe glioma growth and calculate tumor size. 22938469 2012
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE The precise mechanisms governing the direct effects of IFN-β and a combination of IFN-β and TMZ in gliomas are not yet fully understood. 21805051 2011
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE In the present study, we sought to examine whether human NSCs genetically modified to express both CD and IFN-beta genes intensified antitumor effect on experimental glioma. 19893595 2010
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Cationic liposome-mediated interferon-beta (IFN-beta) gene transfer has been found to induce regression of experimental glioma. 18220319 2008
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 AlteredExpression disease BEFREE Exogenously added human interferon-beta (HuIFN-beta) protein possesses a remarkable antiproliferative activity in human glioma and melanoma. 16343929 2005
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Transfer of interferon beta gene via cationic liposomes has been found to induce regression of experimental glioma. 14965379 2004
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Interferon-beta gene transfer could induce apoptosis in interferon-beta protein-resistant tumor cells, such as glioma, melanoma, and renal cell carcinoma. 15546502 2004
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Antitumor effect of an adeno-associated virus vector containing the human interferon-beta gene on experimental intracranial human glioma. 11856487 2002
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE We previously demonstrated that intratumoral administration of liposomes containing the murine interferon beta (IFN-beta) gene [lip(pSV2muIFN-beta)] resulted in stronger growth-inhibitory effect on GL261 (H-2b) mouse glioma inoculated in brains of syngeneic C57BL/6 mice than conventional exogenous IFN-beta administration, and histologic evaluation revealed the massive infiltration of T lymphocytes (CD8 > CD4) within the residual tumor. 10982152 2000
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 AlteredExpression disease BEFREE In the present study, the synergistic effect of mild hyperthermia in combination with gene expression of interferon-beta (IFN-beta) was examined in vitro in the human glioma cell line U87MG. 10395172 1999
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Effect of human interferon beta gene transfer upon human glioma, transplanted into nude mouse brain, involves induced natural killer cells. 9875676 1998
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 GeneticVariation disease BEFREE Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. 1998958 1991