Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE We conclude that eNOS signaling induced by glioma cells-secreted IL-8 regulates endothelial barrier function in the context of glioblastoma involving S-nitrosylation of VE-cadherin and p120. 31440166 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Taken together, our data provide a plausible mechanism for CXCL8-modulated glioma progression, which suggests that CXCL8 may represent a potential therapeutic target in the prevention and treatment of gliomas. 31686858 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE This was demonstrated using the argininocalix[4]arene 1 in miRNA therapeutic approaches performed on three well-described experimental model systems: (1) the induction of apoptosis by antimiR-221 in glioma U251 cells; (2) the induction of apoptosis by premiR-124 in U251 cells; and (3) the inhibition of pro-inflammatory IL-8 and IL-6 genes in cystic fibrosis IB3-1 cells. 31733592 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE Immunofluorescence results showed that there was obviously decreased IRGM, CD206, and IL-8 expression in the mice glioma of Lenti-IRGM group than Lenti-HK control group. 30288851 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation disease BEFREE The overall analysis showed that increased circulating interleukin-6 (IL-6) [SMD 0.81 (95% CI: 0.21-1.40; P = .008)], interleukin-8 (IL-8) [SMD 1.01 (95% CI: 0.17-1.84; P = .018)], interleukin-17 (IL-17) [SMD 1.12 (95% CI: 0.26-1.98; P = .011)], tumor necrosis factor-α (TNF-α) [SMD 1.80 (95% CI: 1.03-2.56; P = .000)], transforming growth factor-β (TGF-β) [SMD 10.55 (95% CI: 5.59-15.51; P = .000)], and C-reactive protein (CRP) [SMD 0.95 (95% CI: 0.75-1.15; P = .000)] levels were significantly associated with glioma risk. 31599129 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE We identified highly upregulated interleukin 8 (IL-8)-CXCR2 axis in tumor cells in high-grade human glioma and AAT-treated orthotopic GBM tumors. 30236892 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE We next discovered that GRK5 knockdown inhibits the nuclear factor kappa B (NF-κB) pathway, thus resulting in downregulation of key downstream secretory products CCL2, IL-6 and IL-8 in glioma cell conditioned medium (CM). 30662593 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy. 29189120 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE We found that various GBM tumor-upregulated genes such as IL6, IL8 and CCL2 are also actively expressed in glioma cell lines, playing differential and cooperative roles in promoting proliferation, invasion, angiogenesis and macrophage polarization in vitro. 28007636 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation disease BEFREE In conclusion, we determined that there is a lack of evidence suggesting a significant association between the IL-8 rs4073 and rs2227306 gene polymorphisms and the development of glioma in a Chinese population. 27706570 2016
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Similar data were obtained on IL-8 gene regulation in the other glioma cell line analyzed, T98G. 26449498 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation disease BEFREE To the best of our knowledge, this is the first report in the literature that the IL-8 -251 AA genotype and A allele were at a higher risk for glioma. 26249370 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Upon γ-irradiation of glioma cells, IκBζ expression is enhanced, and subsequently serves as a transcriptional activator of the tumor promoting cytokines interleukin (IL-6), IL-8 and chemokine (C-X-C motif) ligand 1 (CXCL1) that are known to be involved in glioma associated inflammatory processes. 26398661 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Our data indicate that IL-8 autocrine is responsible for the invasive phenotype of glioma and IL-8 may be a useful prognostic marker for glioma and novel therapeutic target for glioma invasion intervention. 25870011 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE We observed that extracellular nucleotides controlled IL-8/CXCL8 and monocyte chemoattractant protein 1 (MCP-1/CCL2) release by U251MG and U87MG human glioma cell lines via P2X7 and P2Y6 receptor activation. 25445541 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE High expression of both MIF (58.8%) and IL-8 (52.9%) was significantly associated with high-grade gliomas and increased microvessels in tumors, but only high expression of MIF was closely related to tumor recurrence (P = 0.001). 21725855 2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Our data indicate that IL-8 is necessary but not solely responsible for glioma cell invasion and mediates its effect in an autocrine manner. 20577780 2011
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Although high tissue levels of inflammatory cytokines, such as interleukin (IL)-6, IL-8 and transforming growth factor-beta, have been observed in glioma patients, the mechanisms underlying this phenomenon remain to be elucidated. 16465418 2006
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE We previously showed that in glioma, anoxia increases expression of IL-8, a chemokine and angiogenic factor. 10050881 1999
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE These results suggest that antisense IL-8 gene therapy could be beneficial in gliomas where autocrine stimulation by IL-8 is implicated. 8523090 1995
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE IL-8 mRNA was found in 2 of 5 low grade gliomas, in 8 of 9 high grade gliomas. 7699419 1994