Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE There may be a weak association between the IL-13 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities. 29402849 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE We examined the activation of AP-1 family of transcription factors (c-Jun, Fra-1, Jun-D, c-Fos, and Jun-B) after treating U251, A172 (IL-13Rα2 +ve) and T98G (IL-13Rα2 -ve) glioma cell lines with IL-13 by RT-qPCR, and immunocytochemistry (ICC). 30572904 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles. 28583903 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 AlteredExpression disease BEFREE Furthermore, U87 cells treated with IL-13 and MPI together could increase both STAT6 and P63 expression, which attenuated glioma cell proliferation, invasion and migration compared with cells treated with IL-13 alone. 28443896 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE Additionally, TTP were found inversely correlated with IL-13 in glioma specimens. 27424080 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. 27623944 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE The present study aimed to determine whether polymorphisms in IL-10-1082A/G, IL-12p40 1188C/A, and IL-13+2044G/A (rs20541) are associated with the incidence of glioma in Iraqi patients. 26516307 2015
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE No association between IL-4/IL-13 pathway genetic polymorphisms and glioma risk was observed in the overall population, although a significant association was found between rs2234248 and glioblastoma when stratified by histological subtype (log-additive model, OR 1.57, 95 % CI 1.11-2.24). 25472582 2015
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE T cells redirected to interleukin-13Rα2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1. 24841514 2014
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE More studies with larger sample size are warranted to further elucidate the impact of the IL13 rs20541 polymorphism on glioma risk. 23395224 2013
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE However, in the stratified analyses, we found the IL13 rs1800925 polymorphism was significantly associated with decreased risk for glioma (CT vs. TT: OR=0.72, 95%CI=0.55-0.93; CT/TT vs. TT: OR=0.76, 95%CI=0.62-0.89). 23246181 2013
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE We show that these IL13 dTcs were efficient in killing IL13Rα2(+) glioma cell targets with abundant secretion of cytokines IL2 and IFNγ, and they displayed enhanced tumor-induced expansion versus control unmodified T cells in vitro. 22966020 2012
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045). 21196282 2011
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively). 20406895 2010
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE MV-GFP-H(AA)-IL-13 was generated from the Edmonston-NSe vaccine strain, by displaying human IL-13 at the C-terminus of the H protein, and introducing CD46 and signaling lymphocyte activation molecule (SLAM)-ablating mutations in H. The IL-13 retargeted virus showed significant cytopathic effect (CPE) against IL-13Ralpha2 overexpressing glioma lines, and lack of CPE/viral replication in normal human astrocytes and normal human fibroblasts not expressing IL-13Ralpha2. 18665158 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 AlteredExpression disease BEFREE Anti-IL-13Ralpha2(scFv)-PE38 showed significant antitumor activity in immunodeficient mice with s.c. glioma tumors.Both i.p. and i.t. routes of administration showed antitumor activity in a dose-dependent manner. 18566228 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE This enables selective binding and signal transduction on encountering the glioma-restricted IL-13 alpha2 receptor (IL-13Ralpha2). 18559603 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 GeneticVariation disease BEFREE Glioma patients (n = 456) and controls (n = 541) were genotyped for genetic variants in IL4, IL4R, and IL13 and tested for total IgE levels (n = 248 controls and 289 cases). 17548690 2007
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE We examined both neutralization of an IL13-based cytotoxin's glioma cell killing and direct receptor binding of the new IL13 mutants. 15068667 2004
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE To examine if IL-13Ralpha2 is the tumor-associated site for IL-13, we stably transfected normal Chinese hamster ovary (CHO) cells and glioma G-26 cells to express either human (h) or murine (m) IL-13Ralpha2. 12192597 2003
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE We hypothesized that alpha-helix D is the site II of the cytokine that binds IL13Ralpha1, a component of the normal tissue heterodimeric signaling IL13/4 receptor (IL13/4R), and that alpha-helix D independently binds a monomeric IL13Ralpha2 receptor, which is a non-signaling glioma-restricted receptor for IL13. 12189139 2002
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE This glioma-associated receptor for IL13 is interleukin 4 (IL4)-independent. 11418305 2001
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE Since it appears that primarily the least differentiated forms of gliomas possess IL13 binding sites in abundance, it is plausible that IL 13 receptor expressed in low-grade gliomas might be a prognostically significant marker associated with their progression to high-grade gliomas. 11083073 2000
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE In addition, mutated IL13-based cytotoxins directed specifically toward glioma-associated sites are arguably the most active anti-glioma agents. 10952023 2000
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.100 Biomarker disease BEFREE We introduced mutations into human (h) IL13 to determine the site(s) involved in interaction with the shared receptor and/or the glioma-associated receptor. 10514477 1999