Kirsten rat sarcoma viral oncogene (KRAS), a vital factor for the ERK pathway, was directly targeted by miR-134 through its binding with the 3'-UTR of KRAS in glioma.
In univariate analysis, both progression-free survival (PFS) and overall survival (OS) of glioma patients with low miR-134 expression were significantly shorter than those with high miR-134 expression (both p<0.001).