Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE miR-21 may regulate the proliferation and apoptosis of human glioma cells by downregulating the expression of the PTEN protein, and miR-21 may represent a potential therapeutic target for the treatment of glioma. 28534371 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Here, we have tried to down-regulate miR-21 expression in glioma cell lines, U87-MG, and C6, by using engineered exosomes, packed with a miR-21-sponge construct. 31482067 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Mouse glioma cells stably expressing a palmitoylated GFP to label EVs were implanted intracranially into syngeneic miR-21-null mice. 31533034 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Human glioma U87 cells were assigned into the blank, negative control (NC), miR-21 mimics, miR-21 inhibitors, siRNA-SPRY1, and miR-21 inhibitors + siRNA-SPRY1 groups, with human HEB cells serving as the normal group. 29316313 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling. 27909726 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Besides, we found that aberrant expression of miR-21 in SWOZ2-BCNU cells is responsible for glioma BCNU-resistance. 29228449 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Besides, we found that aberrant expression of miR-21 in SWOZ2-BCNU cells is responsible for glioma BCNU-resistance. 29228450 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Hazard ratios (HRs) with 95 % confidence intervals (CIs) for overall survival (OS), which compared the expression levels of miRNA-21 in patients with gliomas, were extracted and estimated. 27531352 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE We next conducted mechanistic investigations to explain the secretory mechanisms of extracellular miR-21 in glioma. 27166186 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE These findings suggest that miR-21 is linked to glioma angiogenesis, that miR-21 is unlikely to regulate PTEN, and that miR-21-positive tumor cells do not possess stem cell characteristics. 26701969 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Krüppel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21. 25305446 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Specific knockdown of DDX23 expression suppressed glioma cell proliferation and invasion in vitro and in vivo, which is similar to the function of miR-21. 26121981 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE MicroRNA-21 (miR-21) is an oncomiR overexpressed in GBM, thus controlling important aspects of glioma biology. 26559642 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE Exosomal miR-21 levels in the CSF of glioma patients were found significantly higher than in the controls; whereas no difference was detected in serum-derived exosomal miR-21 expression. 26284486 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE MicroRNA-21 (miR-21) has been reported to be overexpressed in human glioma tissues and cell lines, which is responsible for the malignant progression of glioma. 25446261 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE We found gradual increase in miR-21 and miR-23a levels in all tumor grades whereas miR-7 and miR-137 were significantly down-regulated depending on the glioma grade. 24412320 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. 25279461 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis. 24161395 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE The association of miR-21 expression with clinicopathological factors or the prognosis of glioma patients was also analyzed. 24326156 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE MicroRNA-21 (miR-21) is the most consistently overexpressed miRNA in several cancers including gliomas and is therefore very promising as a useful clinical biomarker and therapeutic target. 23104517 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 AlteredExpression disease BEFREE In conclusion, we show that high expression levels of miR-21 and -30b/c are needed to maintain the TRAIL-resistant phenotype, thus making these miRs as promising therapeutic targets for TRAIL resistance in glioma. 22964638 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE We decided to investigate the expression of the oncogenic miR-21 during normal mouse development and glioma, focusing on PDGF signaling as a potential regulator of miR-21. 22931209 2012
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE These data provide compelling evidence that β-catenin regulation of miR-21 via STAT3 plays a role in glioma cell invasion and proliferation and indicate that STAT3 is a potential therapeutic target for glioma intervention. 22630347 2012
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy. 22853427 2012
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE Several miRNAs have been recently reported to be involved in modulation of glioma development, especially some upregulated miRNAs, such as microRNA-21 (miR-21), which has been found to function as an oncogene in cultured glioblastoma multiforme cells. 22528454 2012