Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.370 | Biomarker | disease | BEFREE | We also summarize clinical experience with RAF and MEK inhibitors in patients with primary brain tumors and describe ongoing clinical trials of RAF inhibitors in glioma. | 31466300 | 2019 | ||||
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0.370 | Biomarker | disease | BEFREE | Zika virus NS5 protein inhibits cell growth and invasion of glioma. | 31230744 | 2019 | ||||
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0.370 | Biomarker | disease | CTD_human | Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. | 23583981 | 2013 | ||||
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0.370 | AlteredExpression | disease | BEFREE | The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. | 21057530 | 2011 | ||||
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0.370 | Biomarker | disease | BEFREE | Our focus on these proteins was due to the fact that they are involved in the PI3K/AKT/mTOR and RAS/RAF/MAPK pathways, known for their contribution to the development and progression of gliomas. | 20533335 | 2010 | ||||
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0.370 | AlteredExpression | disease | BEFREE | The RAF kinase inhibitor sorafenib suppresses ATF5 expression in glioma stem cells and inhibits malignant glioma growth in cell culture and mouse models. | 20495567 | 2010 | ||||
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0.370 | Biomarker | disease | LHGDN | Specifically, we find that activated Raf-1 cooperates with Arf loss or Akt activation to generate gliomas similar to activated KRas under the same conditions. | 18472967 | 2008 | ||||
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0.370 | GeneticVariation | disease | BEFREE | We confirm the importance of this finding by demonstrating a causal role for a constitutively active Raf-1 mutant in glioma formation in mice. | 18472967 | 2008 | ||||
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0.370 | Biomarker | disease | BEFREE | We now report that AAL881, a novel low-molecular weight inhibitor of the kinase activities associated with B-RAF, C-RAF (RAF-1), and VEGF receptor-2 (VEGFR2), showed activity against glioma cell lines and xenografts. | 16951188 | 2006 |