Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 AlteredExpression disease BEFREE CCL2 was observed to be expressed in the glioma cell line U251 and was inhibited by CCL2 siRNA. 28714025 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 AlteredExpression disease BEFREE We found that various GBM tumor-upregulated genes such as IL6, IL8 and CCL2 are also actively expressed in glioma cell lines, playing differential and cooperative roles in promoting proliferation, invasion, angiogenesis and macrophage polarization in vitro. 28007636 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 Biomarker disease BEFREE Moreover, high millimolar concentrations of ATP increased IL-8 and MCP-1 release by the glioma cells stimulated with suboptimal LPS concentration which were blocked by P2X7 and P2Y6 antagonists. 25445541 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 Biomarker disease BEFREE Next, we overexpressed CCL2 in the U87 glioma line, which has low basal level of CCL2, to investigate the hypothesis that glioma-secreted CCL2 interacts with microglia to affect glioma growth. 22159219 2012
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 AlteredExpression disease BEFREE MCP-1 is believed to play an important role in monocyte infiltration into tumor tissues; however, the relationship between tumor-infiltrating macrophage/microglia (TIM/M) and the expression of chemokines has not been investigated in detail in human glioma samples; therefore, we first examined the expression of several chemokines and chemokine receptors in human tumor cell lines, which included glioma lines, using real-time PCR. 19424580 2009
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 Biomarker disease BEFREE The study results suggest that MCP-1 produced by the glioma cells may mediate macrophage infiltration into the glioma tissue. 8189261 1994
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 Biomarker disease BEFREE Similar monocyte chemotactic proteins (MCP-1) produced by U-105MG human glioma cells have also been identified (Yoshimura, T., Robinson, E. A., Tanaka, S., Appella, E., Kuratsu, J., and Leonard, E. J.(1989) J. Exp.Med.169, 1449-1459). 2211704 1990
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 Biomarker disease BEFREE Screening of a cDNA library from total poly(A) RNA of glioma cell line U-105MG yielded a clone that coded for the entire MCP-1. 2465924 1989