|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, they cooperated to affect transcription of p21 and OCT4.Briefly, these data suggest NSPc1 polycomb protein complex binding and cross‑talk to lncRNAs in glioma H4 cells, offering new insight into the important function of polycomb protein complex and lncRNA interactions in glioma cells and provide a novel view of potential biomarkers and targets for the diagnosis and therapy of glioma.
|
30720120 |
2019 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma.
|
30795814 |
2019 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
The underlying mechanisms may involve the regulation of stem cell markers (CD133, Nestin, OCT4 and Nanog) to reduce the self-renewal ability and regulate the NF-κB1 signaling pathway and inhibit U251s glioma stem-like cell invasion.
|
30509101 |
2019 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
These eGFP-positive-GCs exhibited GSC features and primarily localized to the perivascular region in tumor xenografts, similar to the existence of OCT4-expressing GCs in the perivascular region of human glioblastoma specimens.
|
28216164 |
2018 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that hypoxia can promote the proliferation of glioma stem cells and maintain the characteristics of stem cells through the activation of Notch1 and Oct3/4 or Notch1 activation, affecting the biological characteristics of glioma cells.
|
30405767 |
2018 |
|
POU5F1P3
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771).
|
28952134 |
2017 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that DNA hypomethylation may be a key mechanism underlying the up-regulation of OCT4 in the recurrence of glioma, which facilitates the understanding of the role of stem cells and the exploration of novel strategies for the treatment of recurrent glioma.
|
26925786 |
2016 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
We establish that PKM2 was implicated in glioma spheroid differentiation through its interaction with Oct4, a major regulator of self-renewal and differentiation in stem cells.
|
24481450 |
2014 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that OCT4 is epigenetically regulated by DNA hypomethylation in primary gliomas, which may provide evidence for the role of DNA methylation in tumor and may present a new direction for developing more powerful strategies to treat glioma in the clinic.
|
23670345 |
2013 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma.
|
21341266 |
2011 |
|
POU5F1P3
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also show that, in glioma-initiating cells, Oct4 is associated with Sox4 and that Oct4-Sox4 complexes cooperatively activate the enhancer activity of the SOX2 gene.
|
21987575 |
2011 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we reported that Oct4, a well-known regulator of self-renewal in embryonic stem cells, was highly expressed in human gliomas and glioma cell lines, and the expression levels were increased in parallel with increasing glioma grades.
|
18985733 |
2009 |