Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE With a cell-penetrating TAT-tag protein, B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a robust glioma stem-cell marker, is found to mediate the effect of USP22 on glioma stemness. 29788550 2018
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE Taken together, the present study suggests that miR-194 inhibits glioma cell EMT by targeting Bmi1 providing novel insights into understanding the pathogenesis of glioma. 28098896 2017
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE The HK2 expression in (a) lentivirus-infected, miR-218 overexpressing and (b) shRNA mediated Bmi1 silenced U87 and U251 glioma cell lines were quantified. 29220380 2017
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE In this work, we found that Shh-Gli1 signaling regulates the expression of one stem cell marker, BMI1 (B cell-specific Moloney murine leukemia virus), in glioma. 27662839 2016
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE Together, this is the first study to show that the inhibition of Bcl11b suppresses glioma cell growth by regulating the expression of the cell cycle regulator p21 and stemness-associated genes (Sox-2/Bmi-1). 26096706 2016
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE These findings suggest that the IDH1R132H‑HIF‑1α‑miR‑128a‑Bmi‑1 pathway is involved in glioma cell proliferation. 26324126 2015
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE The BMI1 mRNA in glioma was remarkably up-regulated, 176.3% as much as that in peri-cancerous tissues (P<0.05). 25858624 2015
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. 25262972 2015
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE Taken together, these findings suggest that Bmi-1 promotes glioma cell migration and invasion via NF-κB-mediated upregulation of MMP-3. 25252846 2014
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE In summary, we identified the over-expressed BMI1 as a promising therapeutic target for glioma stem cells, and suggest that the signaling pathways associated with activated BMI1 in promoting tumor growth may be different from those induced by silencing BMI1 in blocking tumor formation. 25526772 2014
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease CTD_human Together, our data suggest that Bmi-1 plays an important role in glioma angiogenesis and therefore could represent a potential target for anti-angiogenic therapy against the disease. 23383216 2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE MiR-128 and SUZ12/BMI1 show opposite expression in human glioblastomas versus normal brain and in glioma stemlike versus neural stem cells. 23733246 2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE We documented that miR-218 also blocked the self-renewal of glioma stem-like cells, consistent with the suggested role of Bmi1 in stem cell growth. 23950210 2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE Both Bmi1 and EZH2 expressions in glioma tissues were significantly higher than those in corresponding nonneoplastic brain tissues (both P<0.001). 24139839 2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE Together, our data suggest that Bmi-1 plays an important role in glioma angiogenesis and therefore could represent a potential target for anti-angiogenic therapy against the disease. 23383216 2013
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE A172 and LN229 glioma cells were engineered to overexpress Bmi-1 via stable transfection or to be silenced for Bmi-1 expression using RNA interfering method. 22967049 2012
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE Cellular depletion of Bmi-1 enhances the sensitivity of glioma cells to apoptosis induced by doxorubicin, BCNU, or UV irradiation. 20035051 2010
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 Biomarker disease BEFREE Our data suggests that down-regulation of miRNA-128 may contribute to glioma and GBM, in part, by coordinately up-regulating ARP5 (ANGPTL6), Bmi-1 and E2F-3a, resulting in the proliferation of undifferentiated GBM cells. 19941032 2010
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE This showed that miR-128 specifically blocked glioma self-renewal consistent with Bmi-1 down-regulation. 19010882 2008
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease LHGDN Of all gliomas, 59% demonstrated aberrant copy numbers of BMI1. 18427816 2008
Entrez Id: 648
Gene Symbol: BMI1
BMI1
0.400 AlteredExpression disease BEFREE This data suggests that BMI1 gene is aberrant at the chromosomal level in a subset of gliomas, and possibly contributes to brain tumour pathogenesis. 18427816 2008