Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.370 | Biomarker | disease | BEFREE | Synthesis and evaluation of <sup>18</sup>F-hexafluorophosphate as a novel PET probe for imaging of sodium/iodide symporter in a murine C6-glioma tumor model. | 29198608 | 2018 | ||||
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0.370 | Biomarker | disease | BEFREE | 131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma. | 26572557 | 2016 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Various cancer cell lines such as thyroid (TPC-1, FRO, B-CPAP), breast (MDA-MB-231), liver (Hep3B), cervical (HeLa), and glioma (U87MG) were transfected with pcDNA3.1/hNIS or pcDNA3.1/opt-hNIS. | 25553100 | 2015 | ||||
|
0.370 | Biomarker | disease | BEFREE | The human glioma cell line U87 was transfected with recombinant lentivirus encoding the hNIS gene under the control of cytomegalovirus promoter (U87-hNIS). | 25000403 | 2014 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | In this study, we have demonstrated that MV strains genetically engineered to express the human sodium iodide symporter (NIS) have significant antitumor activity against glioma lines and orthotopic xenografts; this compares favorably with the MV strain expressing the human carcinoembryonic antigen, which is currently in clinical testing. | 22185260 | 2012 | ||||
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0.370 | Biomarker | disease | BEFREE | In the human glioma transfected with NIS, boron concentration was more than 10 fold higher with 100 mg/kg of NaBF(4), compared to tumor not transfected. | 20921830 | 2010 | ||||
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0.370 | Therapeutic | disease | CTD_human | The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells. | 12489024 | 2003 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | In vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumor cells expressing the sodium/iodide symporter. | 14602867 | 2003 |