Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE This may be useful in up to 3% of glioma patients with BRAF mutations. 31748891 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The case emphasizes the importance of comprehensive assessment based on pathological, genetic and clinical findings and calls for further investigations of non-diffuse glioma with H3F3A K27M and glioma with H3F3A K27M and BRAF V600E. 31254135 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE We recommend that the neuro-oncologist consider using these drugs primarily in the setting of a clinical trial for patients with BRAF-altered glioma in order to advance our knowledge of their efficacy in this patient population. 31466300 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 AlteredExpression disease BEFREE TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF<sup>V600E</sup>/TERT promoter double-mutated glioma. 31391125 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The aim of our study is to investigate the potential use of BRAF mutations on prognosis of glioma patients. 28534272 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE The work from Wang and colleagues identifies an acquired secondary BRAF mutation that confers resistance to pharmacologic BRAF inhibition in a BRAF<sup>V600E</sup> glioma. 30181170 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE The researchers have started a second trial for patients with glioma and other BRAF-mutant tumor types, this time evaluating dabrafenib combined with trametinib. 28062673 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas. 28727518 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. 27611946 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE However, it is unclear whether gliomas harboring BRAF mutations can be invariably regarded as these glioma subtypes or their derivatives. 27792249 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE We were unable to find other examples of glial tumors in public databases with this rare BRAF V600D mutation. 27860162 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE The use of poly(adenosine 5'-diphosphate-ribose) inhibitors may be another way of specifically targeting IDH-mutant gliomas in addition to specific inhibitors, demethylating agents and anti-IDH vaccines. v-raf murine sarcoma viral oncogene homolog B1 (BRAF)-mutant anaplastic xanthoastrocytomas and gangliogliomas may benefit from BRAF and mitogen-activated protein kinase inhibitors. 28901965 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE BRAF alterations are key in certain low-grade gliomas and pediatric gliomas but rarely in high-grade gliomas in adults. 28271343 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE Development of selective inhibitors of BRAF has improved the survival of patients with melanoma and offers potential new therapeutic strategy in children with BRAF-mutant glioma. 27494648 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE For colorectal carcinoma, thyroid cancer, malignant melanoma and gliomas BRAF V600E immunostaining is sufficient for screening purposes. 27350555 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE We discuss differential diagnosis of the tumor, and review previously described diffuse gliomas with the BRAF V600E mutation. 26445861 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. 26384810 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE CDKN2A, and PTEN in high-grade gliomas, followed by BRAF fusions in low-grade gliomas and H3F3A mutations in pediatric gliomas. 26681766 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Our data support clinical evaluation of BRAF(V600E) and EGFR targeted therapy in treating BRAF(V600E) glioma. 26023796 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE One of our E-GBM patients with initial gross total resection quickly recurred within 4 months, required a second resection, and then was placed on vemurafenib; she remains tumor free 21 months after second resection without neuroimaging evidence of residual disease, adding to the growing number of reports of successful treatment of BRAF-mutated glial tumors with drug. 25581727 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Our data indicate that BRAF(V600E) is a common genetic alteration in low-grade glial tumors with neuronal component or differentiation. 25346165 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE In this report, we highlight advances in Nf1-GEM modeling and review new experimental evidence that supports the emerging concept that Nf1- and KIAA1549:BRAF-induced gliomas arise from specific cell types in particular brain locations. 23624918 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE However, a previous study on BRAF V600E mutation in paediatric glioma revealed a BRAF mutation in one of two tested DIAs/DIGs. 23822828 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE The growth inhibitory effects of UAI-201 correlated with the BRAF-V600E genotype of the glioma cell lines. 24721513 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE We report a new IDH1 mutation associated with BRAF mutation in a very unusual glial tumor. 24857351 2014